Candidiasis

This study looks at whether a single surgery to replace an infected hip or knee joint can work as well as the usual two-step process for Candida infections. Researchers will review records of 16 patients treated between 2013 and 2021. The goal is to see if the infection clears up…

This study tests whether a genetic test can help decide which leukemia patients need a strong antifungal drug (posaconazole) to prevent serious mold infections during chemotherapy. About 410 adults with acute myeloid leukemia will be randomly assigned to receive the drug or a pla…

This study tests whether a 5-day course of a nasal antiseptic (povidone iodine) can reduce or eliminate Candida auris, a drug-resistant fungus, from the nose of colonized patients. Researchers will enroll 120 adults with a history of C. auris colonization or infection. The goal i…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study evaluates a rapid diagnostic test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy against standard lab methods using samples from 554 patients. The goal is to help hospitals quickly identify and …

This study looks at whether a common yeast infection in babies' mouths, called oral thrush, is linked to severe cavities in early childhood. Researchers will follow 70 children, half with a history of thrush and half without, for two years. They will regularly check teeth and tak…

This study looks at how the antifungal drug rezafungin moves into the abdominal fluid of critically ill patients with a serious fungal infection after abdominal surgery. Researchers will measure drug levels in the blood and belly fluid of 20 patients. The goal is to see if enough…