One surgery instead of two for candida joint infections?
NCT ID NCT07303101
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a single surgery to replace an infected hip or knee joint can work as well as the usual two-step process for Candida infections. Researchers will review records of 16 patients treated between 2013 and 2021. The goal is to see if the infection clears up with just one operation plus antifungal medicine.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- surgical procedure (one-stage prosthesis replacement)
- What this could lead to
- If successful, this could simplify treatment for rare Candida joint infections, reducing the need for multiple surgeries.
- What could go wrong
- This is a small, early study with only 16 participants, so results may not apply widely. The infection could still return.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 16 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult subject having hip or knee prosthesis revision
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient aged over 18 years at the time of prosthesis revision * Operated on at the Strasbourg University Hospitals (HUS) between January 1, 2013, and December 31, 2021 * Hip or knee prosthesis revision * Possible or proven periprosthetic Candida spp. infection according to the EBJIS diagnostic criteria * Minimum of 3 deep samples (joint fluid, preoperative sample, and/or prosthesis sonication) Exclusion Criteria: * Patient undergoing lavage, synovectomy, and implant preservation * Patient not receiving systemic antifungal treatment after prosthesis replacement * Patient with another proven Candida spp. infection or infective endocarditis * Patient for whom suppressive therapy was prescribed prior to surgery.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France
RECRUITINGStrasbourg, 67091, France
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