Bronchiolitis obliterans syndrome

This phase 2 trial tests whether tezepelumab, a biologic drug that blocks a protein called TSLP, can reduce bronchial flare-ups in people who develop bronchiolitis obliterans syndrome (BOS) after an allogeneic stem cell transplant. BOS is a chronic lung condition that causes airw…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This Phase 3 trial tests an inhaled drug called ARINA-1 in 100 people who have had a double lung transplant and are showing early signs of lung function loss. The goal is to see if adding ARINA-1 to standard care can prevent further decline in lung function and improve quality of…

This Phase 3 trial tests an oral drug called belumosudil in adults who have chronic lung allograft dysfunction (CLAD) after a bilateral lung transplant. CLAD is a form of chronic rejection that slowly worsens lung function. The study compares belumosudil to a placebo, both given …

This phase 2 trial tests whether the drug belumosudil can help people who develop bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a stem cell transplant. The study will enroll 45 participants with new or early-stage BOS. Participants will take belumosudil …

This study tests an inhaled drug called LAM-001 in 30 lung transplant patients who have developed chronic rejection (BOS). Participants will inhale LAM-001 or a placebo daily for 48 weeks. The goal is to see if the drug is safe and can slow the decline in lung function.

This early-phase study tests whether airway basal stem cells can safely help children with bronchiolitis obliterans, a chronic lung disease that narrows airways. About 12 children aged 28 days to 18 years will receive the cells via bronchoscopy. Researchers will check for improve…

This study tests a drug called nintedanib in 20 people who developed a lung condition called bronchiolitis obliterans syndrome after a stem cell transplant. Participants take the drug daily for 12 months alongside their usual medications. The main goal is to see if the drug is sa…

This study tests whether a non-invasive breathing test called Forced Oscillation Technique (FOT) can detect bronchiolitis obliterans syndrome (BOS) — a serious lung condition — earlier than standard tests in people who have received a bone marrow transplant. Researchers will comp…

This early-phase study is testing a new imaging agent called [68Ga]CBP8 to see if it can safely and accurately detect collagen buildup (scarring) in the lungs. Researchers will compare scans from healthy volunteers, lung cancer patients, and people with pulmonary fibrosis. The go…

This study is testing whether a special MRI using xenon gas can better detect bronchiolitis obliterans syndrome (BOS), a serious lung condition, in children who have had a stem-cell transplant. Fifteen children aged 6 to 17 will undergo breathing tests and the xenon MRI. The goal…

This study is testing a new type of MRI that uses xenon gas to see how well the lungs are working in people who have had a bone marrow transplant. Researchers will scan 25 transplant patients with or without lung problems, plus 10 healthy volunteers. The goal is to see if this MR…

This study looks at children aged 1 month to 6 years who are hospitalized with a severe respiratory infection caused by adenovirus or rhinovirus. The goal is to compare the airway cells of those who develop a rare lung condition called post-infectious bronchiolitis obliterans (PI…

This study looks for early signs that a treatment called ECP is working in people who have had a lung transplant and developed chronic rejection (CLAD). Researchers will collect blood samples and, for some, lung MRI scans before, during, and after ECP therapy. The goal is to find…

This study follows 2,000 children who receive stem cell transplants to better understand and detect lung injuries that can occur after the procedure. Researchers will track participants for two years, collecting samples and health data to find ways to diagnose problems earlier. T…

This study looks at abnormal cells in the lungs of 15 people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to understand these cells better so doctors can spot the disease earlier in future patients. Participants will have …

This study follows 600 adults who have received a stem cell transplant to learn more about a lung condition called bronchiolitis obliterans syndrome. Researchers will track how common this lung problem is and how it develops over time. No new treatments are being tested; the goal…

This study looks at whether a special CT scan analysis called parametric response mapping (PRM) can detect early signs of chronic lung disease in people who have had a stem cell transplant. Researchers will follow 375 patients for one year to see if PRM patterns predict lung func…