Bronchiolitis

This trial tests whether giving doctors and nurses a standardized guideline for starting and stopping heated high-flow nasal cannula (HHFNC) — a type of breathing support — helps infants with bronchiolitis recover faster. The study includes children under 2 years old with bronchi…

This study will check how well two RSV prevention methods work in real life: a vaccine given to pregnant women and an antibody shot given to newborns. Researchers will follow about 1,100 infants under 6 months old who are hospitalized with severe respiratory infections in Bogotá,…

This study tests whether OM-85 (Broncho-Vaxom), a bacterial extract taken by mouth for 10 days each month, can reduce the number of respiratory infections in children aged 6 months to 5 years who have a history of wheezing. About 525 children will receive either OM-85 or a placeb…

This study compares two methods to prevent RSV, a common virus that can cause serious breathing problems in babies. One method is a vaccine given to pregnant women, which passes protection to the baby before birth. The other is an antibody shot given directly to the newborn. The …

This study aimed to see if a single dose of magnesium sulfate could help infants under 12 months with moderate to severe bronchiolitis breathe easier. Researchers planned to enroll babies in the pediatric ICU and monitor their breathing and any side effects. However, the study wa…

This trial aimed to compare standard nebulized breathing treatments with a positive pressure device in infants aged 2-24 months with moderate to severe bronchiolitis. The goal was to see if the pressurized method reduced hospital admissions. However, the study was withdrawn befor…

This study investigates whether vitamin D levels, genetic variations in the vitamin D receptor, and changes in immune cell mitochondria can help predict which children will develop recurrent wheezing after a bout of bronchiolitis. Researchers will measure these markers in childre…

This study follows 300 pregnant women who had respiratory infections to see if RSV can pass from mother to baby before birth. Researchers will test blood from mothers and umbilical cords for RSV antibodies and viruses. Babies will be tracked for up to 4 years to monitor respirato…

This study looks at ways to reduce the overuse of continuous pulse oximetry (a device that measures oxygen levels) in children hospitalized with bronchiolitis who are not on supplemental oxygen. Researchers are testing educational outreach and feedback strategies across multiple …

This study examines medical records of 1,100 children under 18 from hospitals across China who were hospitalized with RSV-positive bronchiolitis or pneumonia between 2017 and 2021. Researchers aim to understand how the disease is diagnosed and treated, and what it costs families …