Bipolar I disorder

This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…

This study tests an 8-session psychoeducational program called 'Key to Emotional Balance' for adults with bipolar disorder. The program uses positive psychotherapy to help people better regulate their emotions, support recovery, and find more meaning in life. Researchers will com…

This study looks at whether certain immune cells (CD8+ T lymphocytes) show different patterns of gene activity in people with bipolar disorder compared to healthy individuals. Researchers will measure markers that help these cells travel to the brain, and they will also check if …

This lab study tests whether gold nanoparticles can carry lithium directly to brain cells, potentially reducing side effects. Researchers will use neural cells grown from blood samples of people with bipolar disorder and healthy volunteers, plus a mouse model of mania. The goal i…

This study looks at how emotional childhood maltreatment (like verbal abuse or neglect) affects social skills, brain structure, and inflammation in people with bipolar disorder. Researchers will compare 80 people with bipolar disorder and 80 healthy controls, using brain scans, b…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…