Bipolar depression

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This study tests whether taking a daily probiotic supplement can help people who were recently hospitalized for bipolar depression avoid another episode. 80 adults aged 18-65 will be randomly assigned to receive either the probiotic or a placebo pill for several months. Researche…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

This pilot study asks whether the antibiotic minocycline, the supplement N-acetylcysteine (NAC), or both together can ease depression in people with bipolar disorder. Participants continue their usual mood stabilizer while receiving one of the treatments or a placebo. The goal is…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests whether adding a new drug called ABX-002 to current treatments can improve depression symptoms in adults with bipolar disorder. About 30 people with bipolar depression will take the drug for 6 weeks, and some will have brain scans to see how it affects brain chem…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests whether sitting under a bright light for 30 minutes each day for six weeks can improve mood in people with bipolar depression who also tend to be evening types. Seventy adults will be randomly assigned to either the bright light or a placebo device. The goal is t…

This study looks at whether moderate-to-vigorous aerobic exercise, called Braining, can help people with bipolar depression recover faster and prevent future depressive episodes. Fifty-four participants will be split into three groups: one doing supervised aerobic exercise three …

This study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

Researchers at the University of Pittsburgh are testing whether brief exposure to blue light, compared with red light, can stabilize emotional brain function in adolescents and young adults with depressive symptoms. Participants undergo brain scans while viewing light, complete a…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at how low field magnetic stimulation changes brain activity in older adults (age 60+) with bipolar depression. Forty participants receive both real and sham (fake) stimulation on separate days, with brain scans taken before and after each session. The goal is to…

This study observes 65 adults with major depression or bipolar depression who are receiving electroconvulsive therapy (ECT) as part of their routine care. Researchers track how two different anesthetics—ketamine plus propofol versus propofol alone—affect depression severity, suic…

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study is testing whether data from smartphones and wearable devices can predict when a person with depression or bipolar disorder might have another episode. Over 12 months, 540 participants will wear a Fitbit, log daily moods, and complete five check-ins. Researchers will u…