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ECT anesthesia showdown: does ketamine outperform propofol for severe depression?

NCT ID NCT07463911

Knowledge-focused Sponsor: Nurdan Sağbaş Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study observes 65 adults with major depression or bipolar depression who are receiving electroconvulsive therapy (ECT) as part of their routine care. Researchers track how two different anesthetics—ketamine plus propofol versus propofol alone—affect depression severity, suicidal thoughts, and dissociative symptoms over the course of ECT. The goal is to see if ketamine offers faster mood improvement without causing troubling side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 65 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Being an inpatient at Pamukkale University Faculty of Medicine, Department of Mental Health and Diseases Hospital

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosed with depression or bipolar depression according to DSM-5 2. Having an indication for ECT (Electroconvulsive Therapy) Exclusion Criteria: 1. Mental limitations such as intellectual disability 2. Refusal to undergo ECT 3. Patients not suitable for general anesthesia 4. Substance use disorder 5. Alcohol dependence

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder major affective disorder 6 major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar affective disorder Bipolar depression depressed phase Major depression

Contacts and locations

Locations

  • Pamukkale University

    Denizli, 20570, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.