Biliary atresia

This trial tests whether injecting umbilical cord stem cells directly into the liver during Kasai surgery can improve outcomes for infants with biliary atresia, a condition where bile ducts are blocked and the liver becomes damaged. Forty infants aged 30 to 90 days will receive e…

This study compares two feeding approaches after surgery for biliary atresia or choledochal cyst in children. One group starts oral liquids within 24 hours after surgery, while the other follows conventional care and waits over 48 hours for bowel activity to return. Researchers t…

This study tests whether giving oral antibiotics after Kasai surgery can prevent cholangitis, a serious bile duct infection, in infants with biliary atresia. About 356 babies will be randomly assigned to receive either preventive antibiotics or standard care, and they will be fol…

This study tests whether a high-MCT (medium-chain triglyceride) formula given before and after Kasai surgery can improve growth and nutrition in infants with biliary atresia. Biliary atresia is a rare liver condition that blocks bile flow, leading to malnutrition. The trial will …

This study explores whether a computer program can learn to spot signs of cholestasis—a liver condition where bile flow is blocked—by analyzing photos of dirty diapers taken by parents. Researchers will collect images from thousands of infants, both healthy and those with suspect…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help diagnose biliary atresia, a rare liver disease in infants where bile ducts are blocked. After injection, the dye is normally removed through bile and appears in stool. In infants with biliary atres…

This study tests a simple method to diagnose biliary atresia, a serious liver condition in newborns. Infants with suspected cholestasis receive a dye called indocyanine green (ICG) through an IV. Doctors then check the baby's diaper for the dye, which would indicate bile is flowi…

This study aims to uncover the genetic and developmental causes of biliary atresia, a rare condition that leads to liver failure in newborns and accounts for half of all childhood liver transplants worldwide. Researchers will analyze DNA from 1,100 children who have had or need a…

Biliary atresia is a rare but serious liver condition in newborns that often leads to transplantation. This study collects blood, skin, and liver tissue samples from affected children to search for the genes and cellular pathways that cause the disease. By understanding the molec…

This study is creating a large database of information and samples from 1,000 infants with cholestasis, a condition that causes prolonged jaundice. The goal is to better understand diseases like biliary atresia and find ways to improve care. Researchers will track how the disease…

This study is collecting medical information, genetic material, and body fluid samples from over 1,200 children with biliary atresia, a rare liver disease. The goal is to find genes that cause the disease and understand how it progresses in children who still have their own liver…

This study looks at how common tooth staining is in children who had very high bilirubin levels (jaundice) early in life. Researchers will check 120 children with certain liver conditions to see if their teeth are discolored and whether that affects their daily life. The goal is …

This study looks at how a special high-MCT (medium-chain triglyceride) diet affects growth in infants with biliary atresia after Kasai surgery. Researchers will track weight and length in 300 babies under 3 months old. The goal is to gather information, not to test a new treatmen…

This study is looking at whether a substance called FGF19 in the blood, measured before surgery, can help predict how well children with biliary atresia will do after their operation. Researchers will follow 200 children for one year after surgery, checking liver function and whe…