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B cell deficiency
MONDO:0002211A broad classification of disorders where circulating numbers of B lymphocytes are decreased or ineffective. Complement components and the production of antibodies may also be deficient.
Also known as: B-cell deficiency, deficiency of humoral immunity, immunoglobulin heavy chain deficiency, immunoglobulin heavy chain deletion
118 clinical trials for this condition and its sub-types, 5 tagged with B cell deficiency itself.
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Sub-types of B cell deficiency
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Agammaglobulinemia 16 trials · 52 incl. sub-types
10 sub-types
- Syndromic agammaglobulinemia 7 trials · 37 incl. sub-types Sub-types →
- Activated PI3K-delta syndrome 5 trials · 6 incl. sub-types Sub-types →
- Isolated agammaglobulinemia 0 trials · 4 incl. sub-types Sub-types →
- Good syndrome 0 trials
- Agammaglobulinemia 10, autosomal dominant 0 trials
- Agammaglobulinemia 8b, autosomal recessive 0 trials
- Agammaglobulinemia 9, autosomal recessive 0 trials
- Agammaglobulinemia, autosomal recessive, due to BOB1 deficiency 0 trials
- Congenital agammaglobulinemia 0 trials Sub-types →
- Immunodeficiency 61 0 trials
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Hyperimmunoglobulin syndrome 0 trials · 33 incl. sub-types
2 sub-types
- Hyper-IgE syndrome 5 trials · 25 incl. sub-types Sub-types →
- Hyper-IgM syndrome 8 trials · 9 incl. sub-types Sub-types →
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Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types
2 sub-types
- Dysgammaglobulinemia 1 trial · 4 incl. sub-types Sub-types →
- Selective IgD deficiency disease 0 trials
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Immunoglobulin beta deficiency 0 trials
Most studied deeper sub-types
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Can a weekly shot bring antibody levels to safety in untreated immune deficiency?
Disease control Not yet recruitingThis trial tests whether TAK-664, an antibody replacement given under the skin, can quickly raise and maintain protective IgG levels in people with primary immunodeficiency who have never received antibody therapy. Participants receive daily doses for 5 days, then a dose on day 8…
Phase 4 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Can gut bacteria help rebuild immunity after stem cell transplants?
Disease control Not yet recruitingThis trial explores whether transplanting gut bacteria from healthy donors can help restore the immune system in people who have weak immunity after a stem cell transplant. The study first observes immune recovery in patients to identify those with severe deficiency, then gives a…
Phase 1/2 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New IVIG aims to slash infection risk for immune-deficient patients
Disease control Not yet recruitingThis study tests a new medicine called Boya IVIG in 50 people with primary immunodeficiency (CVID or XLA), a condition where the body can't fight infections well. Participants get the drug every 21 or 28 days for a year to see if it keeps serious bacterial infections below one pe…
Phase 3 • Sponsor: Azidus Brasil • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Could a stool sample replace a spinal tap? new study tests Non-Invasive infection detection
Diagnosis Not yet recruitingThis study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 27, 2026 12:36 UTC
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Which infusion pump do patients prefer? new study aims to find out
Symptom relief Not yet recruitingThis study looks at how patients with primary or secondary immunodeficiency feel about using mechanical versus electronic infusion pumps for their immunoglobulin therapy. About 52 adults who have used electronic pumps will try a mechanical pump for three months and then report th…
Sponsor: KORU Medical Systems, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Can a Life-Saving transplant leave hidden scars on a Child's mind?
Knowledge-focused Not yet recruitingThis study looks at children aged 6 to 8 who had a stem cell transplant at least two years ago to treat a primary immunodeficiency—a genetic condition that weakens the immune system. Researchers will use standardized tests and interviews to measure the children's thinking skills,…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC
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New study aims to unravel mysteries of immune disorder complications
Knowledge-focused Not yet recruitingThis study looks back at medical records of about 60 people with primary immune deficiencies who also developed lymphoproliferative disorders (abnormal growth of immune cells). The goal is to track their health over time, including risks of death, cancer, or organ damage. By iden…
Sponsor: Central Hospital, Nancy, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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New study to measure how immune disorders impact Kids' happiness
Knowledge-focused Not yet recruitingThis study looks at how children aged 6 to 18 with inborn errors of immunity (a condition where the immune system doesn't work properly) feel about their quality of life. Researchers will compare their answers to those of healthy children using a special questionnaire. The goal i…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC