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Autosomal dominant optic atrophy
MONDO:0020250An autosomal dominant hereditary condition characterized by optic atrophy and progressive visual loss.
Also known as: ADOA, DOA, optic atrophy, autosomal dominant, dominant optic atrophy
9 clinical trials for this condition and its sub-types, 6 tagged with Autosomal dominant optic atrophy itself.
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Sub-types of Autosomal dominant optic atrophy
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4 sub-types
- Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome 0 trials
- Optic atrophy 8 0 trials
- Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 0 trials
- Optic atrophy, hearing loss, and peripheral neuropathy, autosomal dominant 0 trials
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Optic atrophy 3 0 trials
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Optic atrophy 5 0 trials
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New eye injection aims to slow genetic blindness
Disease control OngoingThis study tests a new medicine called PYC-001, given as an injection into the eye, for people with a genetic condition that damages the optic nerve (OPA1 optic atrophy). The main goal is to check if the treatment is safe and tolerable. About 18 adults will receive a single dose,…
Phase 1 • Sponsor: PYC Therapeutics • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Could vitamin B3 save sight in rare optic nerve disease?
Disease control OngoingThis study tests whether high-dose nicotinamide (vitamin B3) is safe and can help people with dominant optic atrophy, a rare genetic disease that slowly damages the optic nerve and causes vision loss. Researchers will give 25 adults 3 grams of nicotinamide daily and monitor for s…
Phase 2/3 • Sponsor: University Hospital, Angers • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New app could spot eye disease from your couch
Diagnosis By invitation onlyThis study is testing a smartphone app called NEDS EyeCTester to see if it can help detect active eye disease early in people with conditions like optic nerve or macular disease. About 100 participants will use the app at home, and researchers will compare the results to standard…
Sponsor: Neuro-Eye Diagnostic Systems, LLC • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC