Autoinflammatory syndrome
MONDO:0019751A group of disorders of the innate immune system characterized by attacks of seemingly unprovoked inflammation without significant levels of either autoantibodies or autoreactive T cells more characteristic of autoimmune disease.
207 clinical trials for this condition and its sub-types, 21 tagged with Autoinflammatory syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Autoinflammatory syndrome
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Sarcoidosis 61 trials · 84 incl. sub-types
8 sub-types
- Pulmonary sarcoidosis 20 trials
- Cardiac sarcoidosis 19 trials
- Blau syndrome 3 trials
- Neurosarcoidosis 2 trials Sub-types →
- Skin sarcoidosis 2 trials
- Löfgren syndrome 0 trials
- Hypercalcemic sarcoidosis 0 trials
- Uveoparotid fever 0 trials
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Periodic fever syndrome 2 trials · 25 incl. sub-types
3 sub-types
- Hereditary periodic fever syndrome 5 trials · 24 incl. sub-types Sub-types →
- Periodic fever syndrome of childhood 0 trials
- Unexplained periodic fever syndrome 0 trials
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Type 1 interferonopathy 4 trials · 21 incl. sub-types
9 sub-types
- Type 1 interferonopathy of childhood 0 trials · 19 incl. sub-types Sub-types →
- TREX1-related type 1 interferonopathy 0 trials · 5 incl. sub-types Sub-types →
- ADAR-related type 1 interferonopathy 0 trials · 1 incl. sub-types Sub-types →
- IFIH1-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2A-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2B-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2C-related type 1 interferonopathy 0 trials Sub-types →
- RNU7-1-related type 1 interferonopathy 0 trials Sub-types →
- SAMHD1-related type 1 interferonopathy 0 trials Sub-types →
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Autoinflammatory syndrome of childhood 0 trials · 19 incl. sub-types
1 sub-type
- Type 1 interferonopathy of childhood 0 trials · 19 incl. sub-types Sub-types →
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VEXAS syndrome 18 trials
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Adult-onset Still disease 12 trials
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Pyoderma gangrenosum 10 trials
4 sub-types
- Classic pyoderma gangrenosum 3 trials
- Bullous pyoderma gangrenosum 0 trials
- Pustular pyoderma gangrenosum 0 trials
- Vegetative pyoderma gangrenosum 0 trials
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Idiopathic recurrent pericarditis 8 trials
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PFAPA syndrome 6 trials
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Chronic recurrent multifocal osteomyelitis 3 trials · 4 incl. sub-types
3 sub-types
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SAPHO syndrome 3 trials
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Schnitzler syndrome 1 trial
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Cherubism 1 trial
1 sub-type
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PAPASH syndrome 0 trials
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Autoinflammatory disease, X-linked 0 trials
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2 sub-types
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Magic syndrome 0 trials
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2 sub-types
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Psoriasis 14, pustular 0 trials
Most studied deeper sub-types
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New arthritis drug trial for kids: could filgotinib help?
Disease control Stopped earlyThis study is testing the drug filgotinib in children aged 8 to 17 with juvenile idiopathic arthritis (JIA), a condition causing joint pain and swelling. The goal is to see how the drug moves through the body and if it is safe. Ten children with moderate to severe JIA that is not…
Phase 1 • Sponsor: Alfasigma S.p.A. • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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Experimental drug TPN-101 tested in rare childhood brain disease
Disease control Stopped earlyThis study tested a drug called TPN-101 (censavudine) in people with Aicardi-Goutières syndrome, a rare genetic disorder that causes severe brain inflammation. The trial enrolled only 4 participants and aimed to see if the drug could reduce immune system overactivity and check fo…
Phase 2 • Sponsor: Transposon Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Promising drug for rare skin ulcers shows early potential
Disease control Stopped earlyThis study tested a drug called spesolimab in 5 adults with moderate to severe pyoderma gangrenosum, a rare autoimmune disease that causes painful skin ulcers. The goal was to see if the drug could help heal the ulcers and to understand how the body's immune system responds. The …
Phase 2 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Sarcoidosis drug study halted after just 3 patients
Disease control Stopped earlyThis study tested whether the drug maraviroc could reduce inflammation in the lungs of people with active sarcoidosis. Participants took the drug for 6 weeks and had two lung exams (bronchoscopy) to measure immune cells before and after treatment. Only 3 people enrolled, and the …
Sponsor: Kevin F. Gibson • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Promising drug trial for painful skin ulcers halted early
Disease control Stopped earlyThis study tested a drug called vilobelimab for people with pyoderma gangrenosum, a rare condition causing painful skin ulcers. The trial aimed to see if the drug could completely close the ulcers compared to a placebo. It included 54 adults and was stopped early, so the results …
Phase 3 • Sponsor: InflaRx GmbH • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New wound therapy for rare skin disease shows early promise
Disease control Stopped earlyThis study tested a treatment for pyoderma gangrenosum, a rare skin condition that causes painful, hard-to-heal ulcers. Researchers used a special wound covering made from donated placenta tissue (EpiFix) followed by skin grafts. The study was stopped early after only 5 people en…
Phase 4 • Sponsor: Louisiana State University Health Sciences Center in New Orleans • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug namilumab tested for lung sarcoidosis – but trial halted early
Disease control Stopped earlyThis study tested namilumab, an experimental drug, in 107 people with chronic pulmonary sarcoidosis, a condition causing lung inflammation. The trial was randomized and placebo-controlled, but it was terminated early. The goal was to see if namilumab could reduce the need for res…
Phase 2 • Sponsor: Kinevant Sciences GmbH • Aim: Disease control
Last updated Jun 26, 2026 15:32 UTC
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New PET tracer aims to reveal hidden immune activity in tumors and arteries
Diagnosis Stopped earlyThis Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…
Phase 2 • Sponsor: Universitair Ziekenhuis Brussel • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
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Sarcoidosis drug study halted after only 2 patients enrolled
Symptom relief Stopped earlyThis study tested whether Acthar gel could improve symptoms and lung function in people with sarcoidosis, a disease that causes inflammation in the lungs. Researchers also checked if a blood marker called CXCL9 could predict how well the treatment works. Only 2 people joined befo…
Phase 4 • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Jun 27, 2026 12:27 UTC
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New lung camera could replace needle biopsies
Knowledge-focused Stopped earlyThis study aimed to see if a tiny camera on a thin tube (bronchoscopy) could help doctors diagnose diffuse lung diseases without needing a surgical lung biopsy. The camera takes live microscopic images of the air sacs. The study was stopped early, but it involved 38 adults with c…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC