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Atypical endometrial hyperplasia
MONDO:0006096An endometrial hyperplasia characterized by cytologic and architectural changes which may lead to endometrial carcinoma. Despite the atypical features and possible course, there is debate on whether to consider this a neoplasm. The relationship with endometrial intraepithelial neoplasia is also unclear.
Also known as: atypical hyperplasia of endometrium, atypical hyperplasia of the endometrium, endometrial hyperplasia with atypia
29 clinical trials for this condition and its sub-types, 28 tagged with Atypical endometrial hyperplasia itself.
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Could a hormonal IUD replace surgery for some uterine cancers?
Disease control OngoingThis study looks at whether a hormonal intrauterine device (IUD) alone or combined with the drug everolimus can treat precancerous changes or very early-stage endometrial cancer. About 100 women with these conditions will receive the IUD, and some will also take everolimus if the…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Blueberry compound may boost cancer treatment in small trial
Disease control OngoingThis phase II trial tests whether adding pterostilbene, an antioxidant found in blueberries, to the hormone drug megestrol acetate can better slow endometrial cancer growth before hysterectomy. About 44 patients will receive either megestrol acetate alone or with pterostilbene fo…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Could a diabetes drug help prevent uterine cancer?
Disease control OngoingThis study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their …
Phase 2 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Weight-Loss drug plus IUD aimed to save uteruses – but trial never started
Disease control CancelledThis study planned to test whether combining the weight-loss drug semaglutide with a hormone-releasing IUD could reverse endometrial hyperplasia (a precancerous condition) in premenopausal women with obesity, allowing them to keep their uterus. The trial was withdrawn before enro…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Ice pack on the belly may ease pain after keyhole hysterectomy
Symptom relief By invitation onlyThis study tests whether applying an ice pack to the lower abdomen after vNOTES hysterectomy can lower pain and reduce the need for painkillers. 122 women having surgery for benign conditions will be randomly assigned to receive either standard care or standard care plus ice pack…
Sponsor: Erzincan Military Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Promising scan study for endometrial cancer pulled before it started
Knowledge-focused CancelledThis study aimed to see if a type of PET/MRI scan could predict which women with early endometrial cancer or a precancerous condition would respond to hormone therapy. It planned to enroll 8 women and follow them for 6 months. However, the study was withdrawn before any participa…
Phase 2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC