Atrial septal defect

This study looks at children aged 2 to 18 having minimally invasive heart surgery to fix simple defects. Researchers compare two approaches: giving sugammadex in doses adjusted to real-time nerve monitoring, versus letting muscle relaxation wear off naturally. The goal is to see …

This 24-month study tests whether adding umbilical cord stem cells (AdiaVita) to glutathione therapy helps improve autism symptoms in children ages 3-12. About 100 kids will be randomly assigned to get either glutathione alone or glutathione plus stem cell infusions. Parents and …

This trial asks whether giving children a low-dose ketamine infusion after heart surgery can protect their brains from damage. Children aged 1 to 60 months undergoing surgery for certain congenital heart defects will receive either ketamine at one of two doses or no ketamine. Res…

This study tests whether a caregiver-led telehealth program can help autistic children ages 5 to 12 who still have bowel accidents after completing treatment for bedwetting. About 150 children will take part. The program teaches caregivers strategies to manage encopresis, with th…

This study tests whether a combination of umbilical cord stem cells and glutathione can safely improve autism symptoms in 100 people aged 3 and older. Participants receive either the stem cell product plus glutathione, or a placebo plus glutathione, with the option to switch grou…

This study is tracking 145 people who have a hole in their heart (atrial septal defect) and received the CeraFlex closure device. Researchers want to see how well the device works in real-world settings, focusing on safety and successful closure of the hole at 6 months. The devic…

This study tests whether spironolactone, a common diuretic, can improve learning and behavior in children aged 3–10 with NCOR gene mutations, which are linked to autism spectrum disorder. Only 2 children will be enrolled, and researchers will measure changes in intelligence and a…

This study tests a drug called DT402 (a form of MDMA) in 20 adults with autism spectrum disorder. The goal is to see if it can reduce the severity of social and communication problems. Participants will take the drug and report their experiences using simple rating scales. It is …

This study tests whether a 16-week behavioral therapy called Pivotal Response Treatment (PRT) works better when done at a center or at home for young children with autism who have language delays. Researchers will compare both groups to children receiving usual care. The goal is …

This study tests whether omega-3 supplements can reduce behavioral problems in children and teens with autism spectrum disorder (ASD). Over 12 weeks, 50 participants aged 6-17 will take omega-3 or a placebo. Researchers will measure changes in behavior, attention, and blood marke…

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) are more likely to have a stroke if they also have a small hole in their heart (called a PFO). About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will…

This study compares children with autism spectrum disorder (ASD) to typically developing children, aged 3 to 5 years. Researchers measure a substance called N-CAD in the blood and use a non-invasive brain imaging technique (fNIRS) to look at brain activity during rest and social …