Atherosclerosis

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This phase 2 trial tests whether an experimental oral drug, SAL0137, can safely lower high levels of lipoprotein(a) — a genetic risk factor for heart attacks and strokes that currently has no approved medication. About 120 adults with elevated Lp(a) and high cardiovascular risk w…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study compares two cholesterol-lowering strategies in 6,000 Chinese patients with very high-risk heart disease. One group aims for ultra-low LDL cholesterol below 1.0 mmol/L, while the other targets a moderate level of 1.0-1.39 mmol/L. Researchers will track heart attacks, s…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This Phase 2 trial tests whether erythrodiol, a natural compound in pomace olive oil, can reduce early signs of atherosclerosis (hardening of the arteries). Twenty-two healthy adults will eat high-fat meals with different doses of erythrodiol, then researchers will measure how th…

This study tests whether adding a drug called Tafolecimab to standard cholesterol-lowering therapy can reduce the risk of another stroke in people who have had a recent stroke or mini-stroke and have high levels of Lp(a), a type of fat in the blood. About 242 participants will re…

This study tests a new drug called YN001 in 40 people who have both atherosclerotic cardiovascular disease (hardening of the arteries) and erectile dysfunction. The trial is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. The…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart conditions will use home devices and answer questionnaires. The goal is to see if this approach helps more patients reach their cholestero…

Researchers are testing an experimental PET imaging tracer called 18F-S2P to see how well it detects inflamed plaques in people with large-artery atherosclerosis. About 200 adults aged 40 to 80 with suspected atherosclerosis receive an intravenous dose of the tracer and then unde…

This study will use heart scans and blood tests to check for early signs of heart disease in 650 adult survivors of childhood cancer. The goal is to better understand who is at highest risk due to past cancer treatments like radiation or chemotherapy. Results will be compared to …

This study will compare how vegan, omnivorous, and carnivore diets affect the way LDL cholesterol particles clump together in the blood, which can lead to artery plaque. Researchers will measure blood lipids and other health markers in 90 adults aged 25-60 who have followed their…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

This study looks at whether two simple tests can spot early signs of heart disease in people under 50 who were recently diagnosed with rheumatoid arthritis (RA). The tests are a blood-based measure called the atherogenic index of plasma and an ultrasound of the neck arteries. The…

This study aims to develop and validate a questionnaire called the ProChange scale, designed to measure the barriers and facilitators to lifestyle changes in people at risk for chronic diseases. The scale will be tested in adults aged 45 and older who receive prevention advice on…

This study looks at whether a specific type of stroke called branch atheromatous disease (BAD) is linked to cognitive decline. Researchers will follow 60 adults aged 18-80 who had this stroke, tracking their thinking and memory over a year. They will also examine if early neurolo…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This study looks at 70 children and teens with juvenile lupus to check for early signs of heart disease using an ultrasound of the neck artery. Researchers will see if things like cholesterol, blood pressure, and lupus activity are linked to artery thickness. No treatment is give…

The MISTIC study will examine 1000 adults to see if early, symptom-free artery disease is linked to thinking and memory problems. Participants will get non-invasive imaging of their arteries and cognitive tests. This is an observational study, not a treatment trial, aiming to imp…

This study aims to understand how fat around the belly and heart relates to inflammation and early signs of heart disease, diabetes, and fatty liver. Researchers will enroll 400 adults without known heart or liver disease. Participants will undergo non-invasive tests like ultraso…

This study will compare a carnivore diet (only animal foods) with a Mediterranean diet (fruits, veggies, grains, legumes) in 30 adults aged 30-60 with high LDL cholesterol. Over 3 weeks, researchers will measure how each diet affects cholesterol clumping, blood fats, and blood ve…

This study will test a new computer program designed to help doctors make better decisions for patients with high cholesterol and heart disease. Researchers will review the medical records of 500 adults and compare the program's recommendations to what doctors actually prescribed…

This study looks at a protein called GARP and related inflammatory markers in the blood of 600 adults with either acute (sudden) or chronic (long-term) coronary syndrome. Participants will have blood drawn during a routine heart catheterization. The goal is to understand how GARP…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This observational study will follow 94 transgender individuals for 12 months to see how gender-affirming hormone therapy affects their mood, stress, and heart health. Researchers will measure inflammation, blood vessel function, and other markers to understand potential cardiova…

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study looks at a protein called GARP in artery plaques from 200 patients having surgery to clear blocked arteries. The goal is to understand how GARP, which is found on platelets and immune cells, might be involved in the inflammation that causes heart attacks and strokes. N…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will see if an artificial intelligence program called CaRi-Heart can help doctors make better decisions about treating heart disease. About 15,000 adults getting a standard heart CT scan will have their images re-analyzed by the AI at no extra cost. The goal is to find…

This study tests whether two widely used anti-platelet drugs, aspirin and clopidogrel, can reduce inflammatory markers in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure changes in monocyte-platelet aggregates, a sign of i…