Aspergillosis
MONDO:0005657Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
57 clinical trials for this condition and its sub-types, 20 tagged with Aspergillosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Aspergillosis
-
Pulmonary aspergilloma 11 trials · 38 incl. sub-types
2 sub-types
- Invasive aspergillosis 31 trials
- Malt worker's lung 0 trials
-
Allergic bronchopulmonary aspergillosis 15 trials
1 sub-type
- Malt worker's lung 0 trials
-
Neuroaspergillosis 1 trial
-
Aspergillus niger infection 0 trials
-
Can an injected biologic cut steroid Flare-Ups in a Tough-to-Treat asthma complication?
Disease control Not yet recruitingResearchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…
Sponsor: Qianfoshan Hospital • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
-
Two antifungal pills go head to head against a fungus that scars the lungs
Disease control Not yet recruitingResearchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…
Phase 3 • Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
-
Can a single injection tame severe asthma in fungal allergy?
Disease control Not yet recruitingThis study is testing whether tezepelumab, an injectable medication, can help people with severe asthma caused by allergic bronchopulmonary aspergillosis (ABPA), a condition where the immune system overreacts to certain fungi. The trial will enroll 10 adults aged 18 to 75 who hav…
Sponsor: Qianfoshan Hospital • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
-
Can a gentler antifungal drug protect liver transplant patients from deadly mold without risking organ rejection?
Disease control Not yet recruitingInvasive mold infections are a major threat to liver transplant recipients, with mortality rates as high as 90%. The standard treatment, voriconazole, can interfere with anti-rejection drugs, increasing the risk of graft loss. This trial tests whether liposomal amphotericin B (Am…
Sponsor: Beijing Friendship Hospital • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
-
Can a cancer drug wake up immune cells to beat HIV-Related infections?
Disease control Not yet recruitingThis study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…
Phase 1/2 • Sponsor: Shanghai Public Health Clinical Center • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
-
New study aims to treat deadly fungus in patients with liver issues
Disease control Not yet recruitingThis study tests a drug called liposomal amphotericin B in 40 ICU patients who have a severe fungal infection (invasive aspergillosis) and liver problems. The drug is given daily for 2 weeks, followed by 4 weeks of monitoring. The goal is to see if it is safe and effective for th…
Sponsor: Southeast University, China • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
-
New study aims to improve inhaler treatment for lung fungus
Knowledge-focused Not yet recruitingThis study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will inhale two different doses on separate days and then have special scans to see whe…
Phase 1 • Sponsor: Radboud University Medical Center • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
-
Scientists hunt for clues to Drug-Resistant fungus in Patients' homes and workplaces
Knowledge-focused Not yet recruitingThis study will analyze respiratory samples from 1,000 patients in France to understand why some Aspergillus fungi become resistant to common antifungal drugs. Researchers will test samples for resistance and collect information about patients' environments, jobs, and medication …
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
-
Tailoring antifungal doses for seniors: a precision approach
Knowledge-focused Not yet recruitingThis study aims to find the best dose of isavuconazole, an antifungal drug, for patients over 60 with invasive fungal infections. Researchers will monitor drug levels in the blood and adjust doses to improve treatment and reduce side effects. The goal is to create personalized do…
Sponsor: Chinese PLA General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC