Aspergillosis
MONDO:0005657Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
56 clinical trials for this condition and its sub-types, 19 tagged with Aspergillosis itself.
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Sub-types of Aspergillosis
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Pulmonary aspergilloma 11 trials · 38 incl. sub-types
2 sub-types
- Invasive aspergillosis 31 trials
- Malt worker's lung 0 trials
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Allergic bronchopulmonary aspergillosis 15 trials
1 sub-type
- Malt worker's lung 0 trials
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Neuroaspergillosis 1 trial
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Aspergillus niger infection 0 trials
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Steroid combo may improve tough lung fungus treatment
Disease control Recruiting nowThis study looks at people with a mix of two lung conditions caused by the fungus Aspergillus: chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Researchers want to see if adding steroid pills to the standard antifungal drug itraconazole works better th…
Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Gene test may help prevent deadly fungal infections in leukemia patients
Disease control Recruiting nowThis study tests whether a genetic test can help decide which leukemia patients need a strong antifungal drug (posaconazole) to prevent serious mold infections during chemotherapy. About 410 adults with acute myeloid leukemia will be randomly assigned to receive the drug or a pla…
Sponsor: Bochud Pierre-Yves • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New PET tracer could spot hidden fungal infections
Diagnosis Recruiting nowThis Phase 1 trial tests a new radioactive tracer called [18F]-Fluorocellobiose ([18F]FCB) for PET/CT scans. The goal is to see if it can help find invasive mold infections in the body. The study includes healthy volunteers and people with known fungal infections. Participants re…
Phase 1 • Sponsor: National Institutes of Health Clinical Center (CC) • Aim: Diagnosis
Last updated Sep 20, 2026 00:00 UTC
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New score could help doctors spot fungal pneumonia faster
Diagnosis Recruiting nowThis study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…
Sponsor: Azienda Ospedaliero-Universitaria Careggi • Aim: Diagnosis
Last updated Jul 04, 2026 00:00 UTC
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Hospital study aims to uncover hidden fungal threat to fragile patients
Knowledge-focused Recruiting nowThis study looks at how a common fungus called Aspergillus spreads in hospital wards and affects blood cancer patients. Researchers will take nasal swabs from 193 adults when they enter and leave the hospital, and also test the air in the ward. The goal is to find links between f…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC