Aortic valve insufficiency

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This study tests a new way to replace a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye, which can harm the kidneys. Instead, doctors will use only ultrasound (echocardiography) to guide the procedure. The goal is to see if this approach is safe and …

This study tests a new device called the J-Valve Transfemoral System in 50 adults who have a heart pump (LVAD) and a severely leaking aortic valve. The valve is replaced through a blood vessel, avoiding open-heart surgery. The goal is to see if it safely stops the leak and improv…

This study tests a new way to replace the aortic valve in people with a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye. Instead, doctors will rely on ultrasound (TEE) to guide the procedure. The goal is to see if this approach is safe and effective,…

This study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …