Anti-MDA5 dermatomyositis

MONDO:1010064

A dermatomyositis characterized by the presence of anti-MDA5 autoantibodies. It is often associated with dermatomyositis rashes, amyopathic or hypomyopathic muscle involvement and interstitial lung disease, frequently as a rapid progressive course and high mortality.

Also known as: MDA-5 DM, MDA5+ DM, anti-melanoma differentiation-associated gene 5 dermatomyositis, clinically amyopathic dermatomyositis

15 clinical trials for this condition and its sub-types, 3 tagged with Anti-MDA5 dermatomyositis itself.

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Where it sits in the disease tree

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↑ Dermatomyositis (100)

Including sub-types (15) Tagged with Anti-MDA5 dermatomyositis (3)

Trials to join now! 8 Not yet recruiting 4 Not yet finished but already full! 2 Completed 1

MRI may replace needle biopsy for muscle disease diagnosis

Diagnosis Completed

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis

Last updated Jun 27, 2026 12:02 UTC

Anti-MDA5 dermatomyositis

Where it sits in the disease tree

MRI may replace needle biopsy for muscle disease diagnosis