Anti-MDA5 dermatomyositis
MONDO:1010064A dermatomyositis characterized by the presence of anti-MDA5 autoantibodies. It is often associated with dermatomyositis rashes, amyopathic or hypomyopathic muscle involvement and interstitial lung disease, frequently as a rapid progressive course and high mortality.
Also known as: MDA-5 DM, MDA5+ DM, anti-melanoma differentiation-associated gene 5 dermatomyositis, clinically amyopathic dermatomyositis
15 clinical trials for this condition and its sub-types, 3 tagged with Anti-MDA5 dermatomyositis itself.
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Experimental drug takes aim at deadly lung complication
Disease control Recruiting nowThis small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…
Phase 2 • Sponsor: University of Miami • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Could a drug calm this rare muscle and lung disease?
Disease control Recruiting nowThis study tests whether tocilizumab, a drug that blocks inflammation, can improve symptoms and breathing in adults with anti-MDA5+ dermatomyositis, a rare autoimmune disease affecting muscles, skin, and lungs. About 110 participants will receive either tocilizumab or a placebo e…
Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC