Adrenal cortex disorder

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

Researchers are testing an experimental oral drug called OMS1620 in 84 healthy adults. The drug blocks the receptor that adrenocorticotrophic hormone (ACTH) uses to signal the adrenal glands. The trial measures whether single and repeated doses are safe, how the drug moves throug…

This trial asks whether baxdrostat, a daily pill that blocks an enzyme involved in aldosterone production, can reduce the overactive hormone-making spots in the adrenal glands of people with primary aldosteronism. Researchers will use specialized PET-CT scans to measure changes i…

This study tests a procedure that uses a thin needle guided by an endoscope to inject alcohol into a benign adrenal tumor that produces too much aldosterone, a hormone that raises blood pressure. The goal is to destroy the tumor without surgery. The trial enrolls 30 adults with l…

This study compares two steroid replacement therapies—methylprednisolone and hydrocortisone—in people whose adrenal glands have stopped working properly due to long-term use of high-dose steroids. The goal is to see whether a single morning dose of methylprednisolone is as good a…

This trial compares two blood pressure targets in people with primary aldosteronism, a hormonal condition that causes high blood pressure. One group aims for a systolic pressure below 120 mmHg (intensive), the other between 120 and 140 mmHg (standard). Over 6 to 10 years, researc…

This study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…

This phase 2 trial tests a new drug called SAL0140 in 50 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. Participants will receive either SAL0140 or a placebo for 12 weeks to see if it safely lowers b…

This study follows 100 adults with congenital adrenal hyperplasia (CAH) who switch from standard steroids to a timed-release hydrocortisone (Efmody). The goal is to see if better mimicking the body's natural cortisol rhythm improves hormone levels, metabolic health, and quality o…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests an experimental drug called QLS1410 for people with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. The trial will compare the drug to a placebo in 60 adults to see if it safely lowers blood pres…

This study tests a drug called osilodrostat in 63 adults with Cushing's syndrome and high blood pressure. The goal is to see if it can safely lower blood pressure by reducing cortisol levels. Participants will take the drug or a placebo for 30 weeks, with doses adjusted based on …

This study compares two strategies for slowly reducing prednisolone (a steroid) in people with stable rheumatoid arthritis. One method splits a 5 mg tablet into halves, the other reduces by 1 mg at a time. Over six months, 206 participants will be followed to see which approach k…

This study looks at whether giving radiation therapy after surgery can help prevent high-risk adrenocortical carcinoma from coming back. Fifty-eight patients who had their tumor completely removed will be randomly assigned to either receive radiation or just be monitored. The mai…

Researchers compare two ways to find which adrenal gland overproduces aldosterone in people with primary aldosteronism. One method uses a metomidate PET-CT scan with a radioactive tracer; the other uses adrenal vein sampling, an invasive catheter procedure. The trial measures how…

This study tests whether measuring certain hormones in a blood sample can accurately identify which patients with primary aldosteronism (a common cause of high blood pressure) have a curable adrenal tumor. Currently, diagnosis often requires an invasive procedure called adrenal v…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This pilot study tests whether adding regular sauna sessions to usual care can help lower blood pressure in people with primary aldosteronism, a condition that causes high blood pressure. Ten adults will attend three 30-minute sauna sessions per week for two weeks while wearing a…

This study tests a structured program to help 40 adolescents and young adults with congenital adrenal hyperplasia (CAH) move from pediatric to adult healthcare. Participants will learn about their condition, emergency preparedness, and self-management. The goal is to see if the p…

This study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuation…

This study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…

This study looks at whether fasting during Ramadan is safe for people with primary adrenal insufficiency, a condition where the adrenal glands don't make enough hormones. Researchers will monitor 35 patients for low blood sugar and dehydration during two weeks of fasting and two …

This observational study will follow 522 adults across Europe who are having surgery to remove an adrenal gland tumor. The goal is to track heart-related complications within 30 days after surgery and understand how different hospitals prepare patients beforehand. By collecting r…