Glucocorticoid-remediable aldosteronism

MONDO:0007080

Familial hyperaldosteronism type I (FH-I) is a rare heritable, glucocorticoid remediable form of primary aldosteronism (PA) characterized by early-onset hypertension, hyperaldosteronism, variable hypokalemia, low plasma renin activity (PRA), and abnormal production of 18-oxocortisol and 18-hydroxycortisol.

Also known as: FH-I, FH1, GRA, aldosteronism, glucocorticoid-remediable, dexamethasone-sensitive hypertension, familial hyperaldosteronism type 1, glucocorticoid-remediable aldosteronism, glucocorticoid-sensitive hypertension

3 clinical trials for this condition and its sub-types, 1 tagged with Glucocorticoid-remediable aldosteronism itself.

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Where it sits in the disease tree

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↑ Familial hyperaldosteronism (2)

Including sub-types (3) Tagged with Glucocorticoid-remediable aldosteronism (1)

Trials to join now! 1 Not yet recruiting 1 Completed 1

New imaging tracer could shed light on adrenal cholesterol

Knowledge-focused Recruiting now

This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

Early phase 1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused

Last updated Jun 27, 2026 08:02 UTC

Glucocorticoid-remediable aldosteronism

Where it sits in the disease tree

New imaging tracer could shed light on adrenal cholesterol