Acute tricyclic antidepressant poisoning

MONDO:0018547

Acute tricyclic antidepressant (TCA) poisoning is a potentially lethal intoxication that is characterized by life-threatening arrhythmias (sinus tachycardias, premature ventricular contractions, ventricular arrhythmias), anticholinergic toxidrome (mydriasis, dry mucous membrane, tachycardia, hypertension), central nervous system toxicity (lethargy, coma, myoclonic jerks), refractory hypotension, and sudden death.

5 clinical trials for this condition and its sub-types, 3 tagged with Acute tricyclic antidepressant poisoning itself.

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↑ Acute disease (4756) ↑ Poisoning (313)

Including sub-types (5) Tagged with Acute tricyclic antidepressant poisoning (3)

Trials to join now! 1 Not yet finished but already full! 1 Completed 1

Could a common Alzheimer's drug tame Poison-Induced delirium?

Symptom relief Recruiting now

This study tests whether rivastigmine, a drug used for Alzheimer's, can quickly calm agitation and confusion caused by poisoning from medications that block certain nerve signals. About 42 people aged 10 and older with this type of delirium will receive either rivastigmine or a p…

Phase 2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief

Last updated Jun 27, 2026 13:03 UTC

Acute tricyclic antidepressant poisoning

Where it sits in the disease tree

Could a common Alzheimer's drug tame Poison-Induced delirium?