Acute lung injury

This study tests whether gently cooling the body (to 34-35°C) combined with muscle-paralyzing drugs can help people with severe lung injury (ARDS) recover. About 340 adults on ventilators will be randomly assigned to cooling plus paralytics or usual care. The main goal is to see …

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study compares two ways of giving breathing support (PEEP) to very premature babies right after birth. One method uses a steady pressure, the other starts high then lowers it. The goal is to see which approach reduces the chance of death or chronic lung disease. Over 900 bab…

This study tests whether a drug called racecadotril can reduce fluid leakage in skin blisters, as a model for what happens in the lungs during Acute Respiratory Distress Syndrome (ARDS). ARDS is a severe lung injury with no effective drug treatments, where patients' lungs fill wi…

This study looks at 37 children with acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers want to see if measuring certain inflammation markers in saliva works as well as measuring them in fluid from the lungs. If saliva works, it could lead to a …

This study looks at two ways of setting a breathing machine (ventilator) for people with sepsis who need help breathing. One method is personalized based on each patient's lung measurements, while the other is a standard approach. Researchers will use CT scans to see how air move…