Acute leukemia of ambiguous lineage
MONDO:0019460An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (WHO, 2001)
Also known as: acute leukaemia of indeterminate lineage, acute leukemia of ambiguous lineage, acute leukemia of indeterminate lineage, hybrid acute leukaemia, hybrid acute leukemia, mixed lineage acute leukaemia, mixed lineage acute leukemia, ALL with myeloid markers
3231 clinical trials for this condition and its sub-types, 53 tagged with Acute leukemia of ambiguous lineage itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Acute leukemia of ambiguous lineage
-
Mixed phenotype acute leukemia 79 trials · 124 incl. sub-types
3 sub-types
- Acute biphenotypic leukemia 88 trials · 91 incl. sub-types Sub-types →
- Mixed phenotype acute leukemia with t(v;11q23.3) 3 trials
- Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) 1 trial
-
Acute undifferentiated leukemia 27 trials
-
Bilineal acute myeloid leukemia 6 trials
Most studied deeper sub-types
-
New study aims to stop blood cancer relapse after transplant
Disease control Not yet recruitingThis study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …
Phase 2 • Sponsor: Medical College of Wisconsin • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
-
New combo aims to wipe out hidden leukemia cells
Disease control Not yet recruitingThis study tests whether adding a new drug called revumenib to the usual treatment (blinatumomab plus chemotherapy) can better clear leftover leukemia cells in people with a specific genetic type of B-cell acute lymphoblastic leukemia (ALL) or mixed-lineage leukemia. About 90 adu…
Phase 2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
-
New hope for rare leukemia: drug cocktail shows promise
Disease control Not yet recruitingThis study tests a combination of two newer drugs, blinatumomab and venetoclax, along with standard chemotherapy, for adults with a rare type of leukemia called acute leukemia of ambiguous lineage (ALAL). The goal is to see if this approach improves survival and remission rates. …
Sponsor: Institute of Hematology & Blood Diseases Hospital, China • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
-
Tweaking donor cells may shield older transplant patients from a dangerous complication
Prevention Not yet recruitingResearchers are testing whether removing a specific type of immune cell, called CD45RA-positive naive T cells, from donor stem cells can prevent graft-versus-host disease in older adults undergoing stem cell transplants for acute leukemia or myelodysplastic syndrome. The trial en…
Phase 2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Prevention
Last updated Sep 16, 2026 00:00 UTC