Actinic keratosis

This trial is testing a reformulated version of a topical drug called Levulan Kerastick, which is applied to actinic keratosis (AK) lesions on the face or forearms. After the drug sits on the skin for a few hours, it is activated by blue light in a process called photodynamic the…

This study tests whether a single session of fractionated laser resurfacing on one forearm can reduce precancerous spots (actinic keratosis) and prevent future non-melanoma skin cancers in older adults with fair skin. Participants are at least 60 years old and have had actinic ke…

This study follows adults with actinic keratosis (precancerous sun-damaged spots) on the face who are already using tirbanibulin ointment as part of their regular care. Researchers want to see if the treatment improves overall skin appearance and texture over 57 days. Participant…

This study tests whether adding calcipotriene to the standard cream fluorouracil works better for people with multiple actinic keratoses (precancerous skin spots). Thirty adults will apply either fluorouracil alone for 2-3 weeks or a combination cream for just 4 days. Researchers…

This study tests a reformulated gel (Levulan Kerastick) combined with blue light therapy to treat actinic keratosis, a common precancerous skin condition. About 160 adults with 4 to 8 mild-to-moderate spots on the face or bald scalp will receive either the active gel or a placebo…

This study tests a reformulated cream (Levulan Kerastick) plus blue light therapy for actinic keratosis, a common precancerous skin condition. About 260 adults with 4-8 spots on one arm will receive either the active treatment or a placebo cream, followed by light exposure. The m…

This study tests whether a cream containing imipramine (an antidepressant) can improve photodynamic therapy (PDT) for actinic keratosis, a common skin pre-cancer. 48 US veterans with fair skin and many pre-cancerous spots will receive PDT on their face and forearms, with imiprami…

This study aims to create a detailed database of how healthy, precancerous, and cancerous skin interacts with light. Researchers will collect optical data from 140 patients with skin carcinomas or actinic keratoses. The goal is to identify unique light patterns (spectroscopic sig…

This trial tests whether combining three light-based treatments can improve sun-damaged facial skin and possibly help prevent skin cancer. Researchers will treat one side of each participant's face with a thulium laser, an Er:Glass laser, and intense pulsed light, while the other…

This study tests whether a laser treatment called fractionated laser resurfacing (FLR) can protect the forearms of older adults from precancerous spots (actinic keratoses) and non-melanoma skin cancer. Participants are 60 or older with fair skin and at least five precancerous spo…

This study tests whether a daily application of 5% niacinamide cream can prevent skin cancer in organ transplant recipients, who are at high risk due to long-term immune-suppressing drugs. Twenty adult transplant recipients with a history of precancerous skin spots and at least o…

This study tests whether a new sunscreen, Anthelios Fluide 100 KA+ UVMune 400, can help prevent actinic keratosis—rough, scaly patches that can turn into skin cancer—in people aged 60 and older who already have many of these spots. Eighty participants will be randomly assigned to…

This pilot study tests whether applying a topical imipramine cream before photodynamic therapy (PDT) can reduce pain and improve treatment of actinic keratoses, which are precancerous skin lesions. Adults with fair skin who are scheduled for PDT on their face, scalp, or forearms …

This early study tests whether adding aluminum chloride hexahydrate, a drug that stops bleeding, to standard 5-fluorouracil cream works better for actinic keratoses—rough, scaly spots from sun damage that can turn into skin cancer. About 32 adults will apply one of two creams to …

This early-stage study tests an experimental ointment called HW211026 in 40 adults with actinic keratosis, a common skin condition caused by sun damage. The main goal is to check if the ointment is safe and how the body absorbs it. Participants will apply the ointment once or sev…