Actinic keratosis
MONDO:0005173A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.
Also known as: actinic (solar) keratosis, actinic keratosis, actinic keratosis (disease), solar keratosis, Senile hyperkeratosis, Senile keratosis, senile keratosis
1488 clinical trials for this condition and its sub-types, 41 tagged with Actinic keratosis itself.
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Can a Two-Drug cream clear precancerous skin spots even when immunity is suppressed?
Disease control Not yet recruitingThis trial tests a topical cream combining 5-fluorouracil and calcipotriene as a field treatment for actinic keratoses, which are rough, precancerous skin spots caused by sun damage. Researchers will compare how well the cream clears these spots in 32 people with normal immune fu…
Sponsor: Cedars-Sinai Medical Center • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New ointment could zap Sun-Damaged skin lesions
Disease control Not yet recruitingThis study tests an ointment called HW211026 in 80 adults with actinic keratosis, rough skin patches caused by sun damage. The goal is to see if the ointment can completely clear these lesions on the face. Participants will use the ointment and be monitored for safety and effecti…
Phase 2 • Sponsor: Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Light therapy vs chemical peels: which zaps precancerous spots better?
Disease control Not yet recruitingThis study compares two treatments for actinic keratoses—rough, scaly spots that can turn into skin cancer—on the arms. One treatment uses a light-sensitizing gel followed by blue light (photodynamic therapy), while the other uses a two-step chemical peel. About 60 adults with sp…
Phase 2 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Freeze then ointment: new combo tackles precancerous skin spots
Disease control Not yet recruitingThis study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for actinic keratosis on the scalp and forehead. About 59 adults with at least 8 spots will receive the combo treatment or a pl…
Phase 3 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Veterans test daily cream to stop face skin cancers
Prevention Not yet recruitingThis Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…
Phase 3 • Sponsor: VA Office of Research and Development • Aim: Prevention
Last updated Aug 23, 2026 00:00 UTC
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Veterans' skin cancer risk may be cut by simple clinic procedures
Prevention Not yet recruitingThis study tests whether two skin treatments—microneedling and a chemical peel—can reduce the number of precancerous spots and skin cancers in older veterans. About 96 veterans aged 60 and older with fair skin and multiple precancerous spots will receive one treatment on one arm,…
Sponsor: VA Office of Research and Development • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC