ACTH-independent Cushing syndrome

MONDO:0020529

A group of endogenous Cushing syndrome that may result from excess secretion of cortisol by either a unilateral and benign, or malignant adrenocortical tumor, or nodular adrenocortical disease.

Also known as: adrenal Cushing syndrome, adrenocorticotropic hormone-independent Cushing syndrome, corticotropin-independent Cushing syndrome

13 clinical trials for this condition and its sub-types, 9 tagged with ACTH-independent Cushing syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Endogenous Cushing syndrome (38)

Sub-types of ACTH-independent Cushing syndrome

Cushing syndrome due to macronodular adrenal hyperplasia 3 trials
3 sub-types
- ACTH-independent macronodular adrenal hyperplasia 1 0 trials
- ACTH-independent macronodular adrenal hyperplasia 2 0 trials
- ACTH-independent macronodular adrenal hyperplasia 3 0 trials
ACTH-independent adrenal Cushing syndrome, somatic 1 trial
Cushing syndrome due to cortisol-producing adrenocortical adenoma 0 trials

Including sub-types (13) Tagged with ACTH-independent Cushing syndrome (9)

Trials to join now! 6 Not yet recruiting 1 Not yet finished but already full! 1 Completed 1

New pill targets hormone imbalance from adrenal tumors

Disease control Completed

This study tested a daily pill called SPI-62 in 30 adults with high cortisol levels caused by a non-cancerous adrenal tumor. The goal was to see if the drug could safely lower blood sugar and improve other health measures. Participants took 2 mg of SPI-62 each day for up to 12 we…

Phase 2 • Sponsor: Sparrow Pharmaceuticals • Aim: Disease control

Last updated Jun 27, 2026 09:05 UTC

ACTH-independent Cushing syndrome

Where it sits in the disease tree

New pill targets hormone imbalance from adrenal tumors