Achalasia
MONDO:0008698A finding indicating the lack of adequate relaxation of the lower esophageal sphincter resulting in difficulty swallowing food.
Also known as: achalasia, achalasia (disease), achalasia of cardia, achalasia of oesophagus, cardiospasm, esophageal achalasia
48 clinical trials for this condition and its sub-types, 35 tagged with Achalasia itself.
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Sub-types of Achalasia
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Idiopathic achalasia 12 trials
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Achalasia, familial esophageal 0 trials
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Battle of the balloons: which achalasia treatment wins?
Disease control CompletedThis study compared two procedures for treating achalasia, a condition where the esophagus doesn't relax properly. One is a balloon dilation (pneumodilation) and the other is a surgery called POEM done through a scope. 132 adults with achalasia were randomly assigned to one treat…
Sponsor: KU Leuven • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New scope treatment eases swallowing woes
Disease control CompletedThis study tested a new procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing hard. In POEM, doctors cut the tight muscle through a small tunnel inside the esophagus, without any cuts on the outside. The goal wa…
Sponsor: Hadassah Medical Organization • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Which POEM technique works best for achalasia? new study aims to find out.
Symptom relief CompletedThis study compares two versions of a procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. About 52 adults with type I or II achalasia will be randomly assigned to receive either the standard circula…
Sponsor: Peking Union Medical College Hospital • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Could adding a balloon stretch to botox help achalasia patients swallow better?
Symptom relief CompletedThis study looks at whether combining Botox injections with a balloon dilation of the esophagus works better than Botox alone for people with achalasia, a rare swallowing disorder. The trial enrolls 50 adults who are not healthy enough for more invasive treatments. Participants a…
Phase 4 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Aug 28, 2026 00:00 UTC
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Nerve system glitches may worsen blood pressure swings during achalasia surgery — a study investigates
Knowledge-focused CompletedThis study looks at whether achalasia patients with autonomic (involuntary) nerve system problems experience more blood pressure instability during a procedure called per-oral endoscopic myotomy (POEM) under general anesthesia. Researchers will test nerve function before surgery …
Sponsor: Gangnam Severance Hospital • Aim: Knowledge-focused
Last updated Jul 24, 2026 00:00 UTC
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Small study seeks clues to weight loss mystery in achalasia
Knowledge-focused CompletedThis study looked at 7 adults with achalasia, a swallowing disorder, to find out why some lose weight and others don't. Researchers monitored body weight and compared differences between the two groups. The goal was to gather information that could lead to better understanding an…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC