New hope for Hard-to-Treat ovarian cancer: drug targets resistant tumors

NCT ID NCT05128825

Recruiting now Disease control Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 22 times

Summary

This study tests a new drug, azenosertib (ZN-c3), in people with a type of ovarian cancer that no longer responds to platinum chemotherapy. About 310 adults with high-grade serous ovarian, fallopian tube, or primary peritoneal cancer will receive the drug to see if it shrinks tumors or slows disease progression. The study focuses on patients whose tumors have a specific protein marker called Cyclin E1.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Site 0101 - Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

Contact
Site 0102 - University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724, United States
Site 0103 - University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Site 0104 - Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Site 0108 - Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Site 0126 - Wilmot Cancer Center
RECRUITING

Rochester, New York, 14642, United States
Site 0132 - Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Site 0135 - Rocky Mountain Cancer Centers
ACTIVE_NOT_RECRUITING

Lone Tree, Colorado, 80218, United States
Site 0143 - HonorHealth
RECRUITING

Phoenix, Arizona, 85016, United States
Site 0146 - Maryland Oncology Hematology, PA
ACTIVE_NOT_RECRUITING

Rockville, Maryland, 20876, United States
Site 0147 - Trihealth Cancer Institute - Harold and Eugen
RECRUITING

Cincinnati, Ohio, 45242, United States
Site 0158 - Hartford HealthCare
RECRUITING

Hartford, Connecticut, 06106, United States
Site 0170-USA Mitchell Cancer Institute
RECRUITING

Mobile, Alabama, 36604, United States
Site 0173 - Mount Sinai Medical Center
RECRUITING

Miami Beach, Florida, 33140, United States
Site 0178 - Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Site 0203 - Texas Oncology
RECRUITING

Tyler, Texas, 75702, United States
Site 0213 - Center of Hope
RECRUITING

Reno, Nevada, 89511, United States
Site 0214-Ohio State University Comprehensive Cancer Center
RECRUITING

Hilliard, Ohio, 43026, United States
Site 0217 - St Vincent Hospital and Health Care Centers
RECRUITING

Indianapolis, Indiana, 46260, United States
Site 0221 - Tufts Medical Center - PPDS
RECRUITING

Boston, Massachusetts, 02111, United States
Site 0226 - CoxHealth
ACTIVE_NOT_RECRUITING

Springfield, Missouri, 65807, United States
Site 0228 - Corewell Health Medical Group West
RECRUITING

Grand Rapids, Michigan, 49503, United States
Site 0231 - Northwell Health Cancer Institute
ACTIVE_NOT_RECRUITING

Manhasset, New York, 11030, United States
Site 0232 - University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Site 0234 - University of Texas Health, Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Site 0236 - Memorial Health
ACTIVE_NOT_RECRUITING

Savannah, Georgia, 31404, United States
Site 0239 - Florida Cancer Specialists - East
RECRUITING

Daytona Beach, Florida, 32117, United States
Site 0243 - Mark H Zangmeister Cancer Center
RECRUITING

Columbus, Ohio, 43219, United States
Site 0251 - Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40202, United States
Site 0258 - UC San Diego Moores Cancer Center
ACTIVE_NOT_RECRUITING

La Jolla, California, 92037, United States
Site 0259 - Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Site 0263 - Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199, United States
Site 0277 - Alliance Cancer Specialist, PC
ACTIVE_NOT_RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Site 0284 - Community Cancer Center North
RECRUITING

Indianapolis, Indiana, 46250, United States
Site 0287 - Ridley Tree Cancer Center
ACTIVE_NOT_RECRUITING

Santa Barbara, California, 93105, United States
Site 0288 - Minnesota Oncology Hematology - Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Site 0295 - Virginia Oncology Associates
RECRUITING

Chesapeake, Virginia, 23320, United States
Site 0307 - Lahey Hospital and Medical Center
RECRUITING

Burlington, Massachusetts, 01805, United States
Site 0308 - Advent Health
RECRUITING

Orlando, Florida, 32803, United States
Site 0316 - Willamette Valley Cancer Institute/Oncology Associates of Oregon
RECRUITING

Eugene, Oregon, 97401, United States
Site 0317 - Nebraska Methodist Hospital
ACTIVE_NOT_RECRUITING

Omaha, Nebraska, 68114, United States
Site 0322 - Inova Schar Cancer Institute
RECRUITING

Fairfax, Virginia, 22031, United States
Site 0323 - Compass Oncology
ACTIVE_NOT_RECRUITING

Vancouver, Washington, 98684, United States
Site 0324 - Illinois Cancer Specialists
ACTIVE_NOT_RECRUITING

Niles, Illinois, 60714, United States
Site 2404 - Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
Site 2405 - Centrum Badan Klinicznych JCI
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-348, Poland
Site 2414 - Med-Polonia Sp. z o.o.
ACTIVE_NOT_RECRUITING

Poznan, Greater Poland Voivodeship, 60-693, Poland
Site 2419 - Bialostockie Centrum Onkologii im. Marii Sklodowskiej-Curie w Bialymstoku
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-027, Poland
Site 2421 - Szpitale Pomorskie Sp. z o. o.
RECRUITING

Gdynia, Pomeranian Voivodeship, 81-519, Poland
Site 2701 - Sir Charles Gairdner Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Site 2702 - Burnside War Memorial Hospital - The Brian Fricker Oncology Centre
RECRUITING

Toorak Gardens, South Australia, 5065, Australia
Site 2707 - Mater Brisbane
RECRUITING

South Brisbane, Queensland, 4101, Australia
Site 2709 - Cancer Research SA
RECRUITING

Adelaide, South Australia, 5037, Australia
Site 2715 - Icon Cancer Centre - Chermside
RECRUITING

Chermside, Queensland, 4032, Australia
Site 2716 - Epworth Healthcare Freemasons
RECRUITING

East Melbourne, Victoria, 3002, Australia
Site 2717 - St John of God Hospital Subiaco
RECRUITING

Subiaco, Western Australia, 6008, Australia
Site 2904 - Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Site 2905 - Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Site 2906 - Gangnam Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 06273, South Korea
Site 2907 - Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Site 2909 - Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Site 3101 - AZORG - Aalst
ACTIVE_NOT_RECRUITING

Aalst, Oost-Vlaanderen, 9300, Belgium
Site 3102 - Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Site 3105 - UZ Leuven
RECRUITING

Leuven, Vlaams Brabant, 3000, Belgium
Site 3302 - Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale
RECRUITING

Naples, Campania, 80131, Italy
Site 3303 - Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti
RECRUITING

Bologna, 40138, Italy
Site 3304 - Fondazione Policlinico Universitario A Gemelli
RECRUITING

Rome, Lazio, 168, Italy
Site 3305 - Istituto Europeo di Oncologia
RECRUITING

Milan, Lombardy, 20141, Italy
Site 3307 - Ospedale San Raffaele S.r.l.
RECRUITING

Milan, Milano, 20132, Italy
Site 3308 - Azienda Ospedaliero Universitaria Di Modena Policlinico
RECRUITING

Modena, Emilia-Romagna, 41124, Italy
Site 3311 - Azienda Ospedaliera Universitaria Integrata Di Verona
RECRUITING

Verona, Veneto, 37126, Italy
Site 3312 - Centro di Riferimento Oncologico
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Site 3501 - Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Site 3502 - Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Site 3511 - Instituto de Investigacion Oncologica Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 8035, Spain
Site 3516 - Hospital Universitario Virgen de La Arrixaca
RECRUITING

Murcia, Murcia, 30120, Spain
Site 3517 - Clinica Universidad de Navarra
RECRUITING

Madrid, Madrid, 28027, Spain
Site 3601 - Centre Georges François Leclerc
RECRUITING

Dijon, Côte-d'Or, 21079, France
Site 3602 - Centre Oscar Lambret
RECRUITING

Lille, Nord, 59000, France
Site 3603 - Institut Claudius Regaud
RECRUITING

Toulouse, Haute-Garonne, 31000, France
Site 3604 - Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Site 3608 - Hospices Civils de Lyon - Hôpital Lyon Sud
RECRUITING

Pierre-Bénite, Rhône, 69310, France
Site 3611 - ICANS - Institut de cancérologie Strasbourg Europe
RECRUITING

Strasbourg, Bas-Rhin, 67200, France
Site 3613 - CHRU Besancon - Hopital Jean Minjoz
RECRUITING

Besançon, Doubs, 25030, France
Site 3614 - Institut de Cancerologie de l'oust
RECRUITING

Saint-Herblain, Pays de la Loire Region, 44800, France
Site 3615 - Hôpital Cochin Port-Royal AP-HP
RECRUITING

Paris, Paris, 75181, France
Site 3616 - Centre Antoine Lacassagne
RECRUITING

Nice, Alpes-Maritimes, 06100, France
Site 3617 - CHU de Brest - Hôpital La Cavale Blanche
RECRUITING

Brest, Finistere, 29200, France
Site 3619 - Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Site 3620 - CHU de Strasbourg - Hopital de Hautepierre
RECRUITING

Strasbourg, 67200, France

Conditions

Explore the condition pages connected to this study.

HIGH-GRADE SEROUS OVARIAN, FALLOPIAN TUBE OR PRIMARY PERITONEAL CANCER