New oral drug targets Hard-to-Treat HER2 cancers
NCT ID NCT05593094
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests an experimental oral drug called ZN-A-1041, alone or with other cancer drugs, in people with HER2-positive advanced solid tumors (including breast cancer that has spread to the brain). The study aims to find safe doses and check how the drug works in the body. About 210 participants will take part across multiple phases.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZN-A-1041 (an experimental oral drug) alone or combined with T-DM1, T-DXd, or other HER2-targeted therapies
- What this could lead to
- If successful, this could provide a new treatment option for people with HER2-positive advanced solid tumors, especially those with brain metastases.
- What could go wrong
- This is an early-phase trial (Phase 1/2) focused on safety and dosing, so it is not yet proven to work. Side effects are unknown, and the drug may not show enough benefit to move forward.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Arizona Clinical Research Center, Inc.;Hematology Oncology Physicians - Aoa
Tucson, Arizona, 85712, United States
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Asst Papa Giovanni XXIII
Bergamo, Lombardy, 24127, Italy
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Auckland City Hospital
Auckland, 1023, New Zealand
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Centre Georges Francois Leclerc
Dijon, 21000, France
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Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes
Lyon, 69373, France
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Centre Oscar Lambret
Lille, 59020, France
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Clatterbridge Cancer Centre
Liverpool, Merseyside, L69 3GL, United Kingdom
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University School of Medicine
Durham, North Carolina, 27710, United States
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EDOG - Institut Claudius Regaud - PPDS
Toulouse, Haute-Garonne, 31059, France
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Fondazione Policlinico Universitario A Gemelli-Rome
Magnago, Lombardy, 20020, Italy
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Fundacion Instituto Valenciano de Oncologia (IVO)
Valencia, 46009, Spain
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Geelong Hospital
Geelong, Victoria, 3220, Australia
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Gustave Roussy
Villejuif, 94800, France
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Hospital Beata Maria Ana
Madrid, 28007, Spain
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Clinico San Carlos
Madrid, 28040, Spain
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Hospital Clinico Universitario de Santiago
Santiago de Compostela, LA Coruna, 15706, Spain
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Ramon y Cajal
A Gudiña, Orense, 32540, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hospital Universitario Virgen del Rocio
Las Cabezas de San Juan, Sevilla, 41730, Spain
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Hospital Universitario de Jaen
Jaén, 23007, Spain
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Institut Paoli-Calmettes
Marseille, 13009, France
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Institut de Cancerologie de l Ouest
Saint-Herblain, 44805, France
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Instituto Oncologico Dr. Rosell-Hospital Universitari Dexeus-Grupo Quironsalud
Barcelona, 08028, Spain
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Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
Argentona, Barcelona, 08310, Spain
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Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST S.r.l - PPDS
Parma, Emilia-Romagna, 43126, Italy
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MD Anderson Cancer Center
Houston, Texas, 77030-4000, United States
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Sunshine Hospital
St Albans, Victoria, 3021, Australia
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TOI Clinical Research
Cerritos, California, 90703-2684, United States
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The Christie
Manchester, Lancashire, M20 4BX, United Kingdom
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UCSF Helen Diller Family CCC
San Francisco, California, 94158, United States
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University of Michigan Hospital
Ann Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill outsmart Tumors' defenses?
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Can a new immune drug outsmart Hard-to-Treat tumors?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Can a new drug shrink Hard-to-Treat tumors?
- Can a new drug shrink Hard-to-Treat tumors?