New Antibody-Drug combo aims to tackle tough lymphoma

NCT ID NCT05139017

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 7 times

Summary

This study tests whether adding the experimental drug zilovertamab vedotin to standard chemotherapy helps people with diffuse large B-cell lymphoma that has come back or not responded to treatment. About 290 adults will be randomly assigned to receive either the new combination or standard chemo alone. The main goals are to see if the combo improves how long people live without their cancer getting worse, and to check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zilovertamab vedotin (an antibody-drug conjugate) combined with standard chemotherapy drugs (rituximab, gemcitabine, oxaliplatin, or bendamustine)
What this could lead to: If successful, this combination could offer a new treatment option for people with relapsed or refractory diffuse large B-cell lymphoma, potentially slowing disease progression.
What could go wrong: This is an early-to-mid-stage trial (phase 2/3) with only 290 participants. The drug may cause side effects like infusion reactions or low blood counts, and it may not prove more effective than current standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B-CELL LYMPHOMA DLBCL

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aarhus Universitetshospital, Skejby ( Site 1701)
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Aberdeen Royal Infirmary ( Site 2104)
COMPLETED

Aberdeen, Aberdeen City, AB25 2ZN, United Kingdom
Alliance Cancer Specialists (ACS) ( Site 8001)
RECRUITING

Horsham, Pennsylvania, 19044, United States
Ankara University Hospital Cebeci-hematology ( Site 1901)
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Aotearoa Clinical Trials ( Site 0501)
RECRUITING

Auckland, 2025, New Zealand
Atlantic Health System ( Site 0116)
COMPLETED

Morristown, New Jersey, 07960, United States
BRP-Hialeah Hospital ( Site 0182)
RECRUITING

Hialeah, Florida, 33013, United States
Bass Medical Group ( Site 0166)
RECRUITING

Walnut Creek, California, 94598, United States
Beijing Cancer hospital ( Site 3000)
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beverly Hills Cancer Center ( Site 0184)
RECRUITING

Beverly Hills, California, 90211, United States
Biocenter ( Site 2401)
RECRUITING

Concepción, Biobio, 4070196, Chile
Blue Ridge Cancer Care ( Site 0169)
RECRUITING

Roanoke, Virginia, 24014, United States
Boca Raton Regional Hospital- Lynn Cancer Institute ( Site 0163)
RECRUITING

Boca Raton, Florida, 33486, United States
Bradfordhill ( Site 2403)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CELAN,S.A ( Site 2603)
RECRUITING

Guatemala City, 1010, Guatemala
CIMCA ( Site 2501)
RECRUITING

San José, 10103, Costa Rica
Carmel Hospital ( Site 1103)
COMPLETED

Haifa, 3436212, Israel
Centro de Infusion Superare ( Site 2701)
COMPLETED

Mexico City, 03104, Mexico
Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologii i Transplantacji Szpiku ( Site 1304)
COMPLETED

Lublin, Lublin Voivodeship, 20-090, Poland
Chongqing University Cancer Hospital-Medical Oncology ( Site 3025)
ACTIVE_NOT_RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Chongqing University Three Gorges Hospital ( Site 3026)
ACTIVE_NOT_RECRUITING

Chongqing, Chongqing Municipality, 404199, China
Chulalongkorn University ( Site 0402)
ACTIVE_NOT_RECRUITING

Pathumwan, Bangkok, 10330, Thailand
Clermont Oncology Center ( Site 0174)
RECRUITING

Clermont, Florida, 34711, United States
Clínica Inmunocel ( Site 2404)
RECRUITING

Santiago, Region M. de Santiago, 7580206, Chile
Clínica RedSalud Vitacura ( Site 2409)
RECRUITING

Santiago, Region M. de Santiago, 7650018, Chile
Clínica San Felipe ( Site 2805)
RECRUITING

Lima, 15072, Peru
Clínicas AUNA Sede Chiclayo ( Site 2803)
RECRUITING

Chiclayo, Lambayeque, 14001, Peru
Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 2004)
ACTIVE_NOT_RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76008, Ukraine
Comprehensive Cancer Centers of Nevada ( Site 0168)
RECRUITING

Las Vegas, Nevada, 89169, United States
Corewell Health ( Site 0162)
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana-Farber Cancer Institute-Lymphoma ( Site 0111)
RECRUITING

Boston, Massachusetts, 02215, United States
Dokuz Eylül Üniversitesi-Hematology ( Site 1905)
RECRUITING

Izmir, 35340, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 1912)
RECRUITING

Yenimahalle, Ankara, 06200, Turkey (Türkiye)
Ege University Medicine of Faculty ( Site 1902)
RECRUITING

Bornova, İzmir, 35100, Turkey (Türkiye)
Emek Medical Center-Hematology Unit ( Site 1102)
COMPLETED

Afula, 1834111, Israel
Evangelismos General Hospital of Athens ( Site 0900)
ACTIVE_NOT_RECRUITING

Athens, Attica, 106 76, Greece
FALP-UIDO ( Site 2400)
COMPLETED

Santiago, Region M. de Santiago, 7500921, Chile
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0801)
ACTIVE_NOT_RECRUITING

Bogotá, Bogota D.C., 110131, Colombia
Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 0400)
ACTIVE_NOT_RECRUITING

Bangkok, Bangkok, 10700, Thailand
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 1204)
COMPLETED

Roma, 00168, Italy
Fudan University Shanghai Cancer Center ( Site 3009)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fukushima Medical University Hospital ( Site 3207)
RECRUITING

Fukushima, 960-1295, Japan
Fundacion Valle del Lili ( Site 0802)
RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
Grampians Health ( Site 1802)
RECRUITING

Ballarat, Victoria, 3350, Australia
Hadassah Medical Center ( Site 1100)
COMPLETED

Jerusalem, 9112001, Israel
Health Pharma Professional Research S.A. de C.V: ( Site 2700)
COMPLETED

Mexico City, Mexico City, 03100, Mexico
Henan Cancer Hospital-hematology department ( Site 3013)
RECRUITING

Zhengzhou, Henan, 450008, China
Hokkaido University Hospital ( Site 3202)
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Hospital Aleman ( Site 2200)
ACTIVE_NOT_RECRUITING

Buenos Aites, Buenos Aires F.D., C1118AAT, Argentina
Hospital Erasto Gaertner ( Site 2302)
RECRUITING

Curitiba, Paraná, 81520-060, Brazil
Hospital Italiano de Buenos Aires ( Site 2203)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina
Hospital Metropolitano - Sede Lindora ( Site 2500)
ACTIVE_NOT_RECRUITING

Santa Ana, Provincia de San José, 10903, Costa Rica
Hospital Nacional Dos De Mayo ( Site 2804)
RECRUITING

Lima, 15087, Peru
Hospital Nacional Edgardo Rebagliati Martins ( Site 2802)
RECRUITING

Lima, 15072, Peru
Hospital Pablo Tobon Uribe ( Site 0804)
RECRUITING

Medellín, Antioquia, 50034, Colombia
Hospital Paulistano ( Site 2300)
RECRUITING

São Paulo, 01321-001, Brazil
Hospital Privado Universitario de Córdoba ( Site 2202)
RECRUITING

Córdoba, Córdoba Province, X5016KEH, Argentina
Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1203)
ACTIVE_NOT_RECRUITING

Rozzano, Milano, 20089, Italy
IC La Serena Research ( Site 2405)
RECRUITING

La Serena, Coquimbo Region, 1720430, Chile
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 2800)
RECRUITING

Surquillo, Muni Metro de Lima, 15038, Peru
IRCCS - AOU di Bologna-Istituto di Ematologia "L. e A. Seragnoli" ( Site 1200)
COMPLETED

Bologna, 40138, Italy
Illinois Cancer Specialists ( Site 8000)
RECRUITING

Niles, Illinois, 60714, United States
Innovative Clinical Research Institute ( Site 0122)
COMPLETED

Whittier, California, 90603, United States
Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2002)
ACTIVE_NOT_RECRUITING

Lviv, Lviv Oblast, 79057, Ukraine
Instituto Alexander Fleming ( Site 2201)
RECRUITING

CABA, C1426ANZ, Argentina
Instituto Médico de Alta Tecnologia S.A.S ( Site 0803)
ACTIVE_NOT_RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Instituto de Investigaciones Clínicas Mar del Plata ( Site 2205)
COMPLETED

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1202)
RECRUITING

Naples, 80131, Italy
Jiangxi Provincial Cancer Hospital ( Site 3005)
RECRUITING

Nanchang, Jiangxi, 330029, China
Kansai Medical University Hospital ( Site 3203)
RECRUITING

Hirakata, Osaka, 573-1191, Japan
Liga Norte Riograndense Contra o Câncer ( Site 2305)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
MEDI-K ( Site 2602)
RECRUITING

Guatemala City, 01009, Guatemala
MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2000)
ACTIVE_NOT_RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine
Maharaj Nakorn Chiang Mai Hospital ( Site 0401)
ACTIVE_NOT_RECRUITING

Chiang Mai, 50200, Thailand
Medivest Centro de Investigación Integral ( Site 2704)
COMPLETED

Chihuahua City, 31203, Mexico
Mega Medipol-Hematology ( Site 1909)
RECRUITING

Istanbul, 34214, Turkey (Türkiye)
Mie University Hospital ( Site 3210)
RECRUITING

Tsu, Mie-ken, 514-8507, Japan
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 1300)
ACTIVE_NOT_RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Hospital Organization Kyushu Cancer Center ( Site 3204)
RECRUITING

Fukuoka, 811-1395, Japan
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine ( Site 2005)
COMPLETED

Kyiv, 03115, Ukraine
New York Medical College ( Site 0113)
RECRUITING

Valhalla, New York, 10595, United States
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0133)
RECRUITING

Louisville, Kentucky, 40207, United States
Oncocentro Valdivia ( Site 2407)
RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile
Oncologos del Occidente ( Site 0800)
ACTIVE_NOT_RECRUITING

Pereira, Risaralda Department, 660001, Colombia
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0177)
RECRUITING

Omaha, Nebraska, 68130, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0188)
RECRUITING

Grand Island, Nebraska, 68803, United States
Ondokuz Mayıs Universitesi ( Site 1907)
COMPLETED

Samsun, 55139, Turkey (Türkiye)
Osaka Metropolitan University Hospital ( Site 3205)
RECRUITING

Osaka, 545-8586, Japan
Palo Verde Hematology/ Oncology Center, Ltd. ( Site 0175)
RECRUITING

Glendale, Arizona, 85304, United States
Pitie Salpetriere University Hospital-Clinical haematology ( Site 0700)
ACTIVE_NOT_RECRUITING

Paris, 75013, France
Pratia MCM Krakow ( Site 1303)
ACTIVE_NOT_RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Pratia Onkologia Katowice ( Site 1306)
ACTIVE_NOT_RECRUITING

Katowice, Silesian Voivodeship, 40-519, Poland
Presbyterian Rust Jorgensen Cancer ( Site 9506)
RECRUITING

Rio Rancho, New Mexico, 87124, United States
Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200)
COMPLETED

Toronto, Ontario, M5G 2M9, Canada
Princess Margaret Hospital ( Site 3101)
ACTIVE_NOT_RECRUITING

Hong Kong, Hong Kong
Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 2601)
RECRUITING

Guatemala City, 01010, Guatemala
Queen Mary Hospital ( Site 3100)
ACTIVE_NOT_RECRUITING

Hong Kong, 000000, Hong Kong
Regional General Hospital of Athens "Laiko" ( Site 0901)
ACTIVE_NOT_RECRUITING

Athens, Attica, 115 26, Greece
Royal Perth Hospital-Haematology ( Site 1801)
RECRUITING

Perth, Western Australia, 6000, Australia
Saint Elizabeth Medical Center Edgewood ( Site 0165)
RECRUITING

Edgewood, Kentucky, 41017, United States
Samsung Medical Center ( Site 0300)
COMPLETED

Seoul, 06351, South Korea
Seoul National University Hospital-Oncology ( Site 0302)
RECRUITING

Seoul, 03080, South Korea
Sichuan Cancer hospital-Oncology ( Site 3021)
RECRUITING

Chengdu, Sichuan, 610041, China
Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 1305)
ACTIVE_NOT_RECRUITING

Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland
St. Vincent Frontier Cancer Center-Research ( Site 0108)
RECRUITING

Billings, Montana, 59102, United States
State non-profit enterprise National Cancer Institute ( Site 2001)
ACTIVE_NOT_RECRUITING

Kyiv, 03022, Ukraine
Sun Yat-sen University Cancer Center-Internal Medicine ( Site 3001)
RECRUITING

Guangzhou, Guangdong, 510060, China
Szpitale Pomorskie Sp. z o. o.-Hematology and Bone Marrow Transplantation Department ( Site 1302)
COMPLETED

Gdynia, Pomeranian Voivodeship, 81-519, Poland
Tennessee Cancer Specialists ( Site 7000)
RECRUITING

Knoxville, Tennessee, 37909, United States
The First Affiliated Hospital Zhejiang University School of Medicine ( Site 3027)
RECRUITING

Hangzhou, Zhejiang, 310003, China
The First Affiliated Hospital of Henan University of Science &Technology ( Site 3029)
ACTIVE_NOT_RECRUITING

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Nanchang University ( Site 3004)
ACTIVE_NOT_RECRUITING

Nanchang, Jiangxi, 330006, China
The First Hospital of Jilin University-Hematology ( Site 3012)
RECRUITING

Changchun, Jilin, 130021, China
The Jikei University Hospital ( Site 3208)
RECRUITING

Minato, Tokyo, 105-8471, Japan
The Royal Cornwall Hospital ( Site 2103)
ACTIVE_NOT_RECRUITING

Truro, England, TR1 3LJ, United Kingdom
Tokai University Hospital ( Site 3212)
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Tokyo Metropolitan Komagome Hospital ( Site 3200)
RECRUITING

Bunkyo, Tokyo, 113-8677, Japan
Townsville University Hospital ( Site 1800)
ACTIVE_NOT_RECRUITING

Townsville, Queensland, 4814, Australia
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 3017)
RECRUITING

Wuhan, Hubei, 430048, China
University College London Hospital-Cancer Clinical Trials Unit ( Site 2100)
ACTIVE_NOT_RECRUITING

London-Camden, London, City of, NW1 2PG, United Kingdom
University Hospital of Alexandroupolis ( Site 0903)
ACTIVE_NOT_RECRUITING

Alexandroupoli, East Macedonia and Thrace, 681 00, Greece
University Hospital,Kyoto Prefectural University of Medicine ( Site 3209)
RECRUITING

Kyoto, 602-8566, Japan
University of Kentucky Chandler Medical Center ( Site 0158)
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland ( Site 0123)
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21201, United States
University of Massachusetts Medical School ( Site 0119)
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Miyazaki Hospital ( Site 3211)
RECRUITING

Miyazaki, 889-1692, Japan
University of Yamanashi Hospital ( Site 3201)
RECRUITING

Chūō, Yamanashi, 409-3898, Japan
Uniwersytecki Szpital Kliniczny-Klinika Hematologii, Nowotworow Krwi i Transplantacji Szpiku ( Site 1301)
COMPLETED

Wroclaw, Lower Silesian Voivodeship, 50-367, Poland
Vanderbilt University Medical Center-Vanderbilt-Ingram Cancer Center ( Site 0156)
COMPLETED

Nashville, Tennessee, 37232, United States
West China Hospital of Sichuan University-Head and Neck Oncology ( Site 3016)
RECRUITING

Chengdu, Sichuan, 610041, China
Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 1309)
RECRUITING

Słupsk, Pomeranian Voivodeship, 76-200, Poland
Yamagata University Hospital ( Site 3206)
RECRUITING

Yamagata, 990-9585, Japan
Zhejiang Cancer Hospital ( Site 3014)
RECRUITING

Hangzhou, Zhejiang, 310000, China
Zhujiang Hospital ( Site 3002)
RECRUITING

Guangzhou, Guangdong, 510280, China
centre hospitalier lyon sud-Service Hématologie ( Site 0702)
ACTIVE_NOT_RECRUITING

Pierre-Bénite, Rhone, 69310, France

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