New hope for GIST patients: drug combo targets resistant tumors

NCT ID NCT06655246

Recruiting now Disease control Sponsor: Kura Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing a new combination of two drugs—ziftomenib and imatinib—in adults with advanced gastrointestinal stromal tumors (GIST) that have stopped responding to imatinib alone. The study will first find a safe dose, then check if the combination can shrink or stabilize tumors. About 157 participants will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ziftomenib (a menin inhibitor) combined with imatinib (Gleevec)
What this could lead to: If it works, this could offer a new treatment option for people with advanced GIST whose cancer has stopped responding to imatinib alone.
What could go wrong: This is a very early (Phase 1) trial with only 157 participants, so it is not yet known if the combination is safe or effective. Side effects are possible, and the drug may not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastrointestinal stromal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROINTESTINAL STROMAL CANCER GASTROINTESTINAL STROMAL CELL TUMORS GASTROINTESTINAL STROMAL NEOPLASM GASTROINTESTINAL STROMAL TUMOR (GIST) GASTROINTESTINAL STROMAL TUMOR (GIST) OF THE GASTROINTESTINAL TRACT GASTROINTESTINAL STROMAL TUMOR, MALIGNANT

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Harvard University
RECRUITING

Boston, Massachusetts, 02215, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Cancer Center
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Cancer Center
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Cancer Center
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan-Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Sarah Cannon Research Institute
RECRUITING

Denver, Colorado, 80220, United States
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute
RECRUITING

Dallas, Texas, 75230, United States
Stanford Cancer Institute
RECRUITING

Palo Alto, California, 94304, United States
Temple University Health System
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCLA Santa Monica Medical Center
RECRUITING

Santa Monica, California, 90404, United States
University Of California, Irvine
RECRUITING

Orange, California, 92868, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California, San Diego
RECRUITING

La Jolla, California, 92093, United States
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States
University of Texas
RECRUITING

Houston, Texas, 77030, United States
University of Texas Health Science Center
RECRUITING

San Antonio, Texas, 78229, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06511, United States

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