New drug YK012 tested in early leukemia trial

NCT ID NCT06580301

Recruiting now Disease control Sponsor: Excyte Biopharma Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial is testing a new drug called YK012 in 46 people with B-cell acute lymphoblastic leukemia (B-ALL). The main goals are to check the drug's safety, find the right dose, and see if it shows any signs of fighting the cancer. Participants will receive YK012 through several cycles of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: YK012 (a drug given by injection)
What this could lead to: If it works, this could point toward a treatment for B-cell acute lymphoblastic leukemia that helps control the disease.
What could go wrong: This is a very early, small trial (Phase 1/2) with only 46 people. It mainly checks safety and dosing, not whether the drug works well. Side effects are possible, and the drug may not be effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia Burkitt lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

Locations

Affiliated Zhongshan Hospital of Dalian University
RECRUITING

Dalian, Liaoning, 116001, China
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, Guangdong, 510080, China
Henan Provincial People's Hospital
RECRUITING

Zhengzhou, Henan, 450003, China
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, 110000, China
Sun Yat-sen Memorial Hospital
RECRUITING

Guangzhou, Guangdong, 510000, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, Guangdong, 510000, China
The Affiliated Hospital of Guizhou Medical University
RECRUITING

Guiyang, Guizhou, 550004, China
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221000, China
The First Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, 130021, China
The Second Affiliated Hospital of Kunming Medical University
RECRUITING

Kunming, Yunnan, 650033, China

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