New weekly shot aims to shed pounds and soothe aching knees

NCT ID NCT07481630

Recruiting now Symptom relief Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Mar 26, 2026 · Last updated May 15, 2026 · Updated 6 times

Summary

This study tests a once-weekly injection called NNC0487-0111 in 400 adults with overweight or obesity and knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain and stiffness compared to a placebo. Participants are randomly assigned to receive either the active drug or a dummy injection for several weeks.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
NOT_YET_RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Medicina Interna e Nutrizione Clinica
NOT_YET_RECRUITING

Naples, Campania, 80131, Italy
Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme
RECRUITING

Aarhus N, 8200, Denmark
Accellacare and KDCILM, LLC
RECRUITING

Wilmington, North Carolina, 28401, United States
Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon
RECRUITING

Yuregir/Adana, 01060, Turkey (Türkiye)
Alpha Recherche Clinique - Lebourgneuf
RECRUITING

Québec, G2J OC4, Canada
Angels Clinical Research Institute
RECRUITING

Miami Lakes, Florida, 33016, United States
Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon
RECRUITING

Çankaya/Ankara, 06800, Turkey (Türkiye)
Ankara Üniversitesi Sağlık Uygulama ve Araştırma Hastaneleri- Fiziksel Tıp ve Rehabilitasyon
RECRUITING

Altındağ/Ankara, 06230, Turkey (Türkiye)
Arizona Research Center, Inc.
RECRUITING

Phoenix, Arizona, 85053, United States
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
RECRUITING

Marousi, 15125, Greece
Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases
RECRUITING

Athens, 11525, Greece
Auxologico San Luca - Endocrinologia e Malattie del Metabolismo
NOT_YET_RECRUITING

Milan, Lombardy, 20149, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia
NOT_YET_RECRUITING

Verona, Veneto, 37126, Italy
CNS Healthcare
RECRUITING

Jacksonville, Florida, 32256, United States
CenExel iResearch, LLC
RECRUITING

Decatur, Georgia, 30030, United States
CenterMed Kraków Sp. z o.o.
RECRUITING

Krakow, 31-530, Poland
CenterMed Kraków Sp. z o.o.
NOT_YET_RECRUITING

Krakow, 31-530, Poland
Centre de Recherche Musculo
RECRUITING

Trois-Rivières, Quebec, G8Z 1Y2, Canada
Centro Especialidades Hermanos Sangro
NOT_YET_RECRUITING

Madrid, 28038, Spain
Centrum Medyczne Intercor Sp. z o.o.
RECRUITING

Bydgoszcz, 85-605, Poland
Centrum Medyczne Intercor Sp. z o.o.
NOT_YET_RECRUITING

Bydgoszcz, 85-605, Poland
Charlottesville Med Research
RECRUITING

Charlottesville, Virginia, 22911, United States
Chase Medical Research LLC
RECRUITING

Hamden, Connecticut, 06517, United States
Chase Medical Research LLC
RECRUITING

Waterbury, Connecticut, 06708, United States
ClinicMed Daniluk, Nowak Spółka Komandytowa
RECRUITING

Bialystok, 15-879, Poland
ClinicMed Daniluk, Nowak Spółka Komandytowa
NOT_YET_RECRUITING

Bialystok, 15-879, Poland
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
RECRUITING

Seville, 41003, Spain
Coastal Carolina Res Ctr
RECRUITING

North Charleston, South Carolina, 29405, United States
Coastal Digestive Health
RECRUITING

Maroochydore, Queensland, 4558, Australia
Dawson Clinical Research
RECRUITING

Guelph, Ontario, N1H 1B1, Canada
Diablo Clinical Research, Inc.
RECRUITING

Walnut Creek, California, 94598, United States
Elite Clinical Trials
RECRUITING

Blackfoot, Idaho, 83221, United States
Emeritus Research Sydney
RECRUITING

Botany, New South Wales, 2019, Australia
Frederiksberg Hospital - Parker Institutet (Artrose)
RECRUITING

Frederiksberg, 2000, Denmark
General Hospital Of Athens Alexandra - Clinical Therapeutics
RECRUITING

Athens, 11528, Greece
Great Lakes Medical Research
RECRUITING

Westfield, New York, 14787, United States
H. Infanta Luisa_Endocrino y Obesidad
RECRUITING

Seville, 41010, Spain
Hamilton Medical Rsrch Grp
NOT_YET_RECRUITING

Hamilton, Ontario, L8L 5G4, Canada
Health Res of Hampton Roads
RECRUITING

Newport News, Virginia, 23606, United States
Heart of Australia
RECRUITING

Chelmer, Queensland, 4068, Australia
Hope Clin Res & Wellness
RECRUITING

Conyers, Georgia, 30094, United States
Hospital General de Valencia
RECRUITING

Valencia, 46014, Spain
Hospital Germans Trias i Pujol
NOT_YET_RECRUITING

Badalona, 08916, Spain
Hospital HM La Esperanza
RECRUITING

Santiago de Compostela, 15705, Spain
Hospital Infanta Sofía
RECRUITING

San Sebastián de Los Reyes (Madrid), 28702, Spain
Hospital Naval Ferrol
RECRUITING

Ferrol, 15405, Spain
Hospital Quirónsalud Málaga
RECRUITING

Málaga, 29004, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Instituto Medico Quirurgico San Rafael
RECRUITING

A Coruña, 15006, Spain
Jubilee Clinical Research, Inc.
RECRUITING

Las Vegas, Nevada, 89106, United States
Karadeniz Teknik Üniversitesi Farabi Hastanesi- Fiziksel Tıp ve Rehabilitasyon
RECRUITING

Trabzon Merkez/Ortahisar/Trabzon, 61080, Turkey (Türkiye)
Kolling Institute
RECRUITING

St Leonards, New South Wales, 2065, Australia
Laiko General Hospital Of Athens - 1st department of Internal Medicine
RECRUITING

Athens, 115 27, Greece
Laser Rejuvenation Clinics Inc.
NOT_YET_RECRUITING

Calgary, Alberta, T2W 4X9, Canada
MC Dr. Atanasov EOOD
RECRUITING

Sofia, 1231, Bulgaria
MC Excelsior OOD
RECRUITING

Sofia, 1407, Bulgaria
MMA MHAT - Sofia, Rheumatology clinic
RECRUITING

Sofia, 1606, Bulgaria
MedVadis Research Watertown
RECRUITING

Waltham, Massachusetts, 02451, United States
Momentum Clinical Research Darlinghurst
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
RECRUITING

Warsaw, 02-637, Poland
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
NOT_YET_RECRUITING

Warsaw, 02-637, Poland
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
RECRUITING

Thessaloniki, 54635, Greece
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Ospedale Civile di Baggiovara - UOC Endocrinologia
NOT_YET_RECRUITING

Modena, Emilia-Romagna, 41126, Italy
Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo
NOT_YET_RECRUITING

Udine, Friuli Venezia Giulia, 33100, Italy
Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia
NOT_YET_RECRUITING

Rome, Lazio, 00128, Italy
Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica
NOT_YET_RECRUITING

San Donato Milanese, Lombardy, 20097, Italy
Sanos Clinic - Herlev
RECRUITING

Herlev, 2730, Denmark
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
RECRUITING

Krakow, 31-826, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
NOT_YET_RECRUITING

Krakow, 31-826, Poland
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
RECRUITING

Thessaloniki, 57001, Greece
UMHAT Sveti Georgi EAD, Plovdiv
RECRUITING

Plovdiv, 4002, Bulgaria
UMHAT Sveti Ivan Rilski EAD, Rheumatology
RECRUITING

Sofia, 1612, Bulgaria
UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology
RECRUITING

Sofia, 1527, Bulgaria
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine
NOT_YET_RECRUITING

Chaïdári, Attica, 12461, Greece
VIP Trials_San Antonio
RECRUITING

San Antonio, Texas, 78230, United States
Zenith clinical research
RECRUITING

Hollywood, Florida, 33021, United States
Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi-Fiziksel Tıp ve Rehabilitasyon
NOT_YET_RECRUITING

Kepez/Çanakkale Merkez/Çanakkale, 17110, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi-Fiziksel Tıp ve Rehabilitasyon
NOT_YET_RECRUITING

Merkez/Battalgazi/Malatya, 44280, Turkey (Türkiye)
İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
RECRUITING

Bahçelievler/İstanbul, 34186, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

KNEE OSTEOARTHRITIS (OA) OBESITY