Waterjet vs. scalpel: new trial tests gentler prostate cancer treatment

NCT ID NCT06651632

Ongoing Disease control Sponsor: PROCEPT BioRobotics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new, less invasive treatment called Aquablation, which uses a high-speed waterjet to remove prostate tissue, to standard surgery (radical prostatectomy) for men with localized prostate cancer. About 280 men will be randomly assigned to one of the two treatments and followed for up to 10 years. The main goals are to see which approach better preserves urinary control and erectile function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aquablation Therapy (waterjet device)
What this could lead to: If successful, Aquablation could offer a less invasive option for treating localized prostate cancer with fewer side effects on urinary control and sexual function compared to full prostate removal.
What could go wrong: This is an early-stage comparison study, and it is not yet known if Aquablation controls cancer as effectively as surgery over the long term. There may be risks of incomplete cancer removal or recurrence.

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Conditions

The condition(s) this trial relates to.

prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CANCER

Contacts and locations

Locations

Adult & Pediatric Urology

Omaha, Nebraska, 68114, United States
Advanced Research

Delray Beach, Florida, 33484, United States
Advocate Aurora Research Institute

Sheboygan, Wisconsin, 53081, United States
Arizona State Urological Institute

Chandler, Arizona, 85224, United States
Boulder Medical Center

Boulder, Colorado, 80304, United States
Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, H2X 0A9, Canada
Chinese University of Hong Kong

Shatin, Hong Kong
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
East Valley Urology Center

Mesa, Arizona, 85206, United States
Endeavor Health

Glenview, Illinois, 60026, United States
Florida Urology Partners

Tampa, Florida, 33606, United States
Georgia Urology

Atlanta, Georgia, 30328, United States
Guy's Hospital

London, SE1 9RT, United Kingdom
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hampshire Hospitals NHS Foundation Trust

Basingstoke, Hamsphire, RG24 7A, United Kingdom
Hospital da Cruz Vermelha

Lisbon, 1549-008, Portugal
Integrated Medical Professionals, PLLC

New York, New York, 10016, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Kansas City Urology Care

North Kansas City, Missouri, 64116, United States
Kearney Urology Center

Kearney, Nebraska, 68847, United States
MUSC Hollings Cancer Center

Charleston, South Carolina, 29425, United States
Mountain View Hospital

Idaho Falls, Idaho, 83401, United States
National Taiwan University Hospital

Taipei, Taiwan
Norfolk & Norwich University Hospital

Colney, Norwich, NR4 7UY, United Kingdom
Potomac Urology

Alexandria, Virginia, 22311, United States
Royal Free Hospital

London, United Kingdom
The Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Tidelands Health Urology

Murrells Inlet, South Carolina, 29576, United States
Trophy Point Urology

Tampa, Florida, 33607, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Miami

Miami, Florida, 33146, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Southern California

Los Angeles, California, 90089, United States
University of Toronto

Toronto, Ontario, M5S3H2, Canada
Universitätsklinikum OWL der Universität Bielefeld

Bielefeld, Germany
Urology Austin

Austin, Texas, 78745, United States
Urology Clinics of North Texas

Dallas, Texas, 75231, United States

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