Waterjet vs. scalpel: new trial tests gentler prostate cancer treatment
NCT ID NCT06651632
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a new, less invasive treatment called Aquablation, which uses a high-speed waterjet to remove prostate tissue, to standard surgery (radical prostatectomy) for men with localized prostate cancer. About 280 men will be randomly assigned to one of the two treatments and followed for up to 10 years. The main goals are to see which approach better preserves urinary control and erectile function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aquablation Therapy (waterjet device)
What this could lead to
If successful, Aquablation could offer a less invasive option for treating localized prostate cancer with fewer side effects on urinary control and sexual function compared to full prostate removal.
What could go wrong
This is an early-stage comparison study, and it is not yet known if Aquablation controls cancer as effectively as surgery over the long term. There may be risks of incomplete cancer removal or recurrence.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LOCALIZED PROSTATE CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Adult & Pediatric Urology
Omaha, Nebraska, 68114, United States
-
Advanced Research
Delray Beach, Florida, 33484, United States
-
Advocate Aurora Research Institute
Sheboygan, Wisconsin, 53081, United States
-
Arizona State Urological Institute
Chandler, Arizona, 85224, United States
-
Boulder Medical Center
Boulder, Colorado, 80304, United States
-
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 0A9, Canada
-
Chinese University of Hong Kong
Shatin, Hong Kong
-
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
-
East Valley Urology Center
Mesa, Arizona, 85206, United States
-
Endeavor Health
Glenview, Illinois, 60026, United States
-
Florida Urology Partners
Tampa, Florida, 33606, United States
-
Georgia Urology
Atlanta, Georgia, 30328, United States
-
Guy's Hospital
London, SE1 9RT, United Kingdom
-
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
-
Hampshire Hospitals NHS Foundation Trust
Basingstoke, Hamsphire, RG24 7A, United Kingdom
-
Hospital da Cruz Vermelha
Lisbon, 1549-008, Portugal
-
Integrated Medical Professionals, PLLC
New York, New York, 10016, United States
-
Johns Hopkins University
Baltimore, Maryland, 21287, United States
-
Kansas City Urology Care
North Kansas City, Missouri, 64116, United States
-
Kearney Urology Center
Kearney, Nebraska, 68847, United States
-
MUSC Hollings Cancer Center
Charleston, South Carolina, 29425, United States
-
Mountain View Hospital
Idaho Falls, Idaho, 83401, United States
-
National Taiwan University Hospital
Taipei, Taiwan
-
Norfolk & Norwich University Hospital
Colney, Norwich, NR4 7UY, United Kingdom
-
Potomac Urology
Alexandria, Virginia, 22311, United States
-
Royal Free Hospital
London, United Kingdom
-
The Royal Marsden Hospital
London, SW3 6JJ, United Kingdom
-
Tidelands Health Urology
Murrells Inlet, South Carolina, 29576, United States
-
Trophy Point Urology
Tampa, Florida, 33607, United States
-
University of Chicago
Chicago, Illinois, 60637, United States
-
University of Miami
Miami, Florida, 33146, United States
-
University of Rochester Medical Center
Rochester, New York, 14642, United States
-
University of Southern California
Los Angeles, California, 90089, United States
-
University of Toronto
Toronto, Ontario, M5S3H2, Canada
-
Universitätsklinikum OWL der Universität Bielefeld
Bielefeld, Germany
-
Urology Austin
Austin, Texas, 78745, United States
-
Urology Clinics of North Texas
Dallas, Texas, 75231, United States