New hope for kids with tough leukemia: drug combo trial launches

NCT ID NCT07156435

Recruiting now Disease control Sponsor: Princess Maxima Center for Pediatric Oncology Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial tests a combination of two chemotherapy drugs—Vyxeos (a liposomal form of daunorubicin and cytarabine) and clofarabine—in 25 children and young adults (ages 1-21) with relapsed or refractory acute myeloid leukemia (AML). The main goal is to find the safest dose of this combination. Researchers hope it will be effective against leukemia that has come back or not responded to standard treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vyxeos (liposomal daunorubicin and cytarabine) combined with clofarabine
What this could lead to: If successful, this could lead to a new treatment option for children with hard-to-treat AML, potentially improving remission rates.
What could go wrong: This is a very early, small Phase 1 trial (25 children) focused on finding the right dose. It may not work as hoped, and side effects like infections are a known risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia childhood acute myeloid leukemia Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY PEDIATRIC AML RELAPSED PEDIATRIC AML

Contacts and locations

Locations

Charité Berlin
RECRUITING

Berlin, Germany
Clinica Pediatrica Fondazione MBBM
RECRUITING

Monza, Italy
Hospital Infantil Universitario Niño Jesús
RECRUITING

Madrid, Spain
Hospital Sant Joan de Déu
RECRUITING

Barcelona, Spain
Hospital Vall D'Hebron
RECRUITING

Barcelona, Spain
Ospedale Pediatrico Bambino Gesu (OPBG)
RECRUITING

Roma, Italy
Princess Maxima Center
RECRUITING

Utrecht, Utrecht, 3584 CS, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, Denmark
St. Anna Kinderspital
RECRUITING

Vienna, Austria
University Children´s Hospital III Essen
RECRUITING

Essen, Germany
Universitätsklinikum Augsburg
RECRUITING

Augsburg, Germany
Universitätsklinikum Frankfurt
RECRUITING

Frankfurt, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, Germany

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