New combo pill shows promise for common CF mutation
NCT ID NCT02070744
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 25 times
Summary
This study tested a combination of two drugs, VX-661 and ivacaftor, in 40 adults with cystic fibrosis who have two copies of the F508del gene mutation. The goal was to see if the combination is safe and improves lung function over 12 weeks. Participants were randomly assigned to receive either the drug combo or a placebo, and those who completed the main study could join an open-label extension where everyone received the active treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Study site
Birmingham, Alabama, United States
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Study site
Palo Alto, California, United States
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Stanford, California, United States
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Altamonte Springs, Florida, United States
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Miami, Florida, United States
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Orlando, Florida, United States
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Tampa, Florida, United States
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Boise, Idaho, United States
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Chicago, Illinois, United States
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Boston, Massachusetts, United States
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New Brunswick, New Jersey, United States
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New York, New York, United States
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Durham, North Carolina, United States
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Cincinnati, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Pittsburgh, Pennsylvania, United States
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Charleston, South Carolina, United States
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Memphis, Tennessee, United States
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Houston, Texas, United States
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Burlington, Vermont, United States
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Colchester, Vermont, United States
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Seattle, Washington, United States
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Milwaukee, Wisconsin, United States
Conditions
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