New pill targets Hard-to-Treat lung cancer mutation

NCT ID NCT07659782

Recruiting now Disease control Sponsor: Verastem, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 7 times

Summary

This trial tests an experimental daily pill, VS-7375, for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12D. Participants must have already tried chemotherapy and an immunotherapy drug. The study looks at whether the drug can shrink tumors and how safe it is, both when used alone and with another cancer medicine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VS-7375 (an oral KRAS G12D inhibitor)
What this could lead to: If successful, this could offer a new targeted treatment option for people with a specific type of advanced lung cancer that has not responded to prior therapies.
What could go wrong: This is an early-phase trial with a small number of participants. The drug may not shrink tumors or may cause side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NON-SMALL CELL LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

ICON Cancer Centre South Brisbane
RECRUITING

Brisbane, Queensland, 4101, Australia
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
START Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
START LA
RECRUITING

Los Angeles, California, 90025, United States
START New Jersey
RECRUITING

East Brunswick, New Jersey, 08816, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.