New shot could tame thyroid eye disease
NCT ID NCT06812325
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests an investigational drug called VRDN-003, given as an injection under the skin, for people with thyroid eye disease. The study involves 320 participants and aims to check the drug's safety and tolerability. Researchers will also measure if it reduces eye bulging. The trial is active but not currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VRDN-003 (a monoclonal antibody injection)
What this could lead to
If successful, this could lead to a new treatment option for thyroid eye disease that may reduce eye bulging and improve symptoms.
What could go wrong
This is still an early-stage trial focused on safety, so it is not yet proven to work. The drug may cause side effects or fail to show benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Abeillon du Payrat
Bron, 69500, France
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Addenbrookes Hospital
Cambridge, United Kingdom
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Advanced Quality Medical Research
Orland Park, Illinois, 60462, United States
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Akdeniz Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı
Antalya, 07059, Turkey (Türkiye)
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Alfa Medical Research
Davie, Florida, 33024, United States
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C A Clinical Trial Corp.
Cape Coral, Florida, 33990, United States
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California Eye Specialists Medical Group INC
Pasadena, California, 91107, United States
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Catalina Eye Care
Tuscon, Arizona, 85712, United States
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Centrum Medyczne Pratia Gdynia
Gdynia, 81-338, Poland
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Centrum Medyczne Pulawska Sp. z o.o.
Piaseczno, 05-500, Poland
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Charite Universitatsmeizin Berlin KoR Campus Virchow Klinikum
Berlin, Germany
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Clinica Universidad de Navarre
Navarrés, Spain
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Continental Clinical Research
Miami, Florida, 33144, United States
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D H Doral Research Center
Doral, Florida, 33132, United States
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DFW Clinical Trials
Carrollton, Texas, 75010, United States
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ETG Lublin
Lublin, 20-412, Poland
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East Coast Institute for Research, LLC
Jacksonville, Florida, 32216, United States
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Edward Jenner Research Group LLC
Plantation, Florida, 33317, United States
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Elevate Clinical Research
Seabrook, Texas, 77586, United States
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Eye Centers of Florida
Fort Myers, Florida, 33901, United States
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Eyeplastx
San Antonio, Texas, 78258, United States
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FOMAT Medical Research
Pismo Beach, California, 93030, United States
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Fraser Eye Care Center
Fraser, Michigan, 48026, United States
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Gazi University Medical Faculty Hospital
Ankara, Turkey (Türkiye)
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Guy's and St Thomas' NHS Foundation Trust
London, SE1 7EH, United Kingdom
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Hacettepe Univeristy Medical Fculty Hospital
Ankara, Turkey (Türkiye)
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Herco Medical and Research Center
Coral Gables, Florida, 33134, United States
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Hospital La Arruzafa
Córdoba, 14012, Spain
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Hospital Provincial de Conxo
A Coruña, 15706, Spain
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Hospital Universitario Miguel Servet Consultas de Oftalmologia
Zaragoza, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hôpital La Pitiélsalpêtrière
Paris, France
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Imperial College Healthcare NHS Trust
London, NW1 5QH, United Kingdom
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Institut Català de Retina
Barcelona, 08017, Spain
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Jackson Clinic
Jackson, Tennessee, 38305, United States
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Johannes Gutenberg University Medical Center Department of Medicine 1
Mainz, Germany
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Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi Göz Hastalıkları Kliniği
Istanbul, Turkey (Türkiye)
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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Moorefields Eye Hospital NHS Foundation Trust
London, United Kingdom
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Neuro Eye Clinical Trials
Houston, Texas, 77074, United States
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Ophthalmic Consultants of Boston
East Weymouth, Massachusetts, 02189, United States
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Optimum Profesorskie Centrum Okulistyki Sp. z o. o.
Gdansk, 80-180, Poland
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Orbital Plastics
Newport Beach, California, 92660, United States
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Pacific Neuroscience Institute
Santa Monica, California, 90404, United States
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Pacific Neuroscience Institute at Saint John's Physician Partners
Torrance, California, 90503, United States
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Pioneer Research Solutions Inc.
Houston, Texas, 77099, United States
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Polimedica PTG
Warsaw, 02-777, Poland
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Retreat Medical Research
Miami, Florida, 33135, United States
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Rutgers New Jersey Medical School
Newark, New Jersey, 07103, United States
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San Antonio Clinical Trials
San Antonio, Texas, 78240, United States
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Santa Familia PTG Lodz
Lodz, 90-302, Poland
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Sarasota Retina Institute
Sarasota, Florida, 34239, United States
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Servicde d'Endocrinologie, Diabetologieet Nutrition Centre Hospitalier Universitaire d'Angers
Angers, France
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Sina Medical Center
Homestead, Florida, 33034, United States
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Southern Clinical Research LLC
Miami, Florida, 33125, United States
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
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United Medical Research Institute
Inglewood, California, 90301, United States
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Universitaetsmedizin Goettingen
Göttingen, 37075, Germany
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Universitatsklinikum Essen
Essen, Germany
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University Hospitals Bristol and Weston NHS Foundation Trust Clinical Research Unit
Bristol, United Kingdom
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University of Missouri Kansas City
Kansas City, Missouri, 64108, United States
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Uniwersytecki Szpital Kliniczny w Białymstoku, Klinika Okulistyki, Centrum Badań Klinicznych
Bialystok, 15-276, Poland
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Warszawski Szpital Okulistyczny
Warsaw, 01-258, Poland