Sickle cell drug voxelotor tested for Long-Term safety in extension study

NCT ID NCT03573882

Terminated Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Nov 18, 2025 · Last updated May 16, 2026 · Updated 19 times

Summary

This study looked at the long-term safety of the drug voxelotor in people with sickle cell disease who had already taken it in a previous study. About 179 participants were enrolled to track side effects and complications like pain crises. The study was terminated early, but the results help understand the drug's safety over time.

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Contacts and locations

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Locations

Abu El Rich Hospital,Cairo University Hospital

Cairo, 11541, Egypt
Academic Medical Center(AMC)

Amsterdam, 1105 AZ, Netherlands
Adana Acibadem Hospital

Adana, 01130, Turkey (Türkiye)
Ain Shams University Hospital

Cairo, Egypt
Alexandria Clinical Research Center, Faculty of Medicine

Alexandria, Egypt
Alexandria Clinical Research Center, Faculty of Medicine, Alexandria University

Alexandria, Egypt
American University of Beirut

Beirut, Lebanon
Arkansas Primary Care Clinic, PA

Little Rock, Arkansas, 72204, United States
Azienda Ospedaliera di Padova

Padova, Padova Veneto, 35128, Italy
Barts Health NHS Trust

London, Greater London, E1 1BB, United Kingdom
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Brigham and Women's Hospital Research Pharmacy

Boston, Massachusetts, 02215, United States
Centres for Disease Control and Prevention

Siaya, Kisumu County, Kenya
Children's Healthcare of Atlanta - Scottish Rite

Atlanta, Georgia, 30342, United States
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Clinical Research Services Unit- Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Clinical and Translational Research Center (CTRC)

Chapel Hill, North Carolina, 27599, United States
Columbia University Medical Center - Herbert Irving Pavilion

New York, New York, 10032, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
ErasmusMC

Rotterdam, 3015 CN, Netherlands
Erciyes Universitesi Tip Fakultesi

Kayseri, 38039, Turkey (Türkiye)
Gertrude's Children's Hospital

Nairobi, Kenya
Guys and St. Thomas Hospital NHS Foundation Trust

Great Maze Pond, London, SE1 9RT, United Kingdom
Homerton University Hospital NHS Foundation Trust

London, Greater London, E9 6SR, United Kingdom
Hôpital Européen Georges Pompidou - Medecine Interne

Paris, 75015, France
Imperial College Healthcare NHS Trust, Hammersmith Hospital

London, W12 0HS, United Kingdom
Indiana Hemophilia and Thrombosis Center

Indianapolis, Indiana, 46260, United States
Investigational Drug Service, Duke University Hospital

Durham, North Carolina, 27710, United States
Jackson Memorial Hospital

Miami, Florida, 33136, United States
Jackson Memorial Hospital (Investigational Drug Services)

Miami, Florida, 33136, United States
Johns Hopkins University/Sickle Cell Infusion Center

Baltimore, Maryland, 21287, United States
KEMRI/CRDR - Kenya Medical Research Insititute - Center for respiratory Disease Research

Nairobi, 00101, Kenya
King's College Hospital

London, SE5 9RS, United Kingdom
Lynn Health Science Institute

Oklahoma City, Oklahoma, 73112, United States
McMillan Cancer Centre

London, WC1E 6AG, United Kingdom
Medical University of South Carolina - Comprehensive Sickle Cell Clinic

Charleston, South Carolina, 29425, United States
Medical University of South Carolina: Investigational Drug Services Pharmacy

Charleston, South Carolina, 29425, United States
Mersin Universitesi Tip Fakultesi Saglik Arastirma ve Uygulama Hastanesi

Mersin, 33343, Turkey (Türkiye)
Methodist Comprehensive Sickle Cell Clinic

Memphis, Tennessee, 38104, United States
Montefiore - Einstein Center for Cancer Care

The Bronx, New York, 10461, United States
Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States
Nini Hospital

Tripoli, Lebanon
Our Lady of the Lake Physician Group-Medical Oncology

Baton Rouge, Louisiana, 70809, United States
St. Jude Affiliate Clinic Baton Rouge

Baton Rouge, Louisiana, 70808, United States
Sultan Qaboos University Hospital

Muscat, 123, Oman
Texas Children's Hospital

Houston, Texas, 77030, United States
Texas Children's Hospital - Investigational Pharmacy

Houston, Texas, 77030, United States
The Egyptian Thalassemia Association ( E.T.A)

Cairo, Egypt
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Toronto General Hospital-University Health Network

Toronto, Ontario, M5G 2C4, Canada
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
UNC Hospitals

Chapel Hill, North Carolina, 27514, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Illinois Hospital and Health Science System

Chicago, Illinois, 60612, United States
University of Illinois at Chicago Clinical Research Center

Chicago, Illinois, 60612, United States
University of Miami

Miami, Florida, 33136, United States
University of Miami Hospital & Clinics/SCCC, Research Pharmacy (Investigational Drug Services)

Miami, Florida, 33136, United States
University of Pittsburgh Medical Center (UPMC)

Pittsburgh, Pennsylvania, 15232, United States
Zagazig University Hospital

Alsharkia, Egypt

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE