New combo therapy for diabetic dialysis patients shows promise

NCT ID NCT02176681

First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 41 times

Summary

This study tested whether adding vildagliptin (a diabetes pill) to insulin helps control blood sugar in people with type 2 diabetes who are on hemodialysis. 70 patients were randomly assigned to receive either insulin alone or insulin plus vildagliptin for 12 weeks. The goal was to see if the combination improved blood sugar levels and reduced dangerous lows (hypoglycemia).

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AURAL Clinique Sainte Anne

    Strasbourg, 67000, France

  • AURAL Colmar

    Colmar, 68000, France

  • AURAL Mulhouse

    Mulhouse, 68070, France

  • AURAL Strasbourg

    Strasbourg, 67200, France

  • CH d'Amiens

    Amiens, 80054, France

  • CH de Besançon

    Besançon, 25030, France

  • CH de Dijon

    Dijon, 21079, France

  • CH de Mulhouse

    Mulhouse, 68070, France

  • CH de Nancy

    Nancy, 54000, France

  • CH de Valenciennes

    Valenciennes, 59300, France

  • Clinique Sainte Anne

    Strasbourg, 67000, France

  • Hospices civils de Colmar

    Colmar, 68024, France

  • Hôpitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Vildagliptin (Galvus) added to insulin

What this could lead to

If successful, this could provide a safe and effective way to improve blood sugar control in diabetic patients on dialysis, potentially reducing complications.

What could go wrong

This is a small, early-phase study (70 participants) that only lasted 12 weeks, so results may not apply to all patients. Adding a new drug also carries risks of side effects or interactions.

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.