Botox-Like shot may simplify hernia repair, early trial hopes

NCT ID NCT07226791

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study tests whether an injection of gemibotulinumtoxinA (a botulinum toxin similar to Botox) can help surgeons close the belly wall during open ventral hernia repair without needing a complex additional procedure. About 200 adults with a midline ventral hernia will receive either the drug or a placebo injection before surgery. Researchers will check how often the belly wall can be closed simply and track any side effects over about 25 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gemibotulinumtoxinA (a botulinum toxin type A injection)
What this could lead to: If it works, this could simplify ventral hernia repair by helping surgeons close the belly wall without needing a more complex procedure.
What could go wrong: This is an early Phase 2 trial with only 200 participants, so results may not apply to everyone. The drug is injected into muscles and could cause weakness or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hernia, Ventral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTRAL HERNIA

Contacts and locations

Locations

Avanza Medical Research Center /ID# 278885
RECRUITING

Pensacola, Florida, 32503, United States
Baylor University Medical Center /ID# 261955
RECRUITING

Dallas, Texas, 75246, United States
CARI Clinical Trials INC /ID# 278844
RECRUITING

Riverside, California, 92504, United States
Carilion Roanoke Memorial Hospital /ID# 278577
RECRUITING

Roanoke, Virginia, 24014, United States
Cleveland Clinic - Cleveland /ID# 277914
RECRUITING

Cleveland, Ohio, 44195, United States
Integrity Clinical Research /ID# 278710
COMPLETED

Wichita, Kansas, 67202, United States
Mayo Clinic Hospital Rochester /ID# 278995
RECRUITING

Rochester, Minnesota, 55905, United States
Medical Research Center /ID# 278680
RECRUITING

Miami, Florida, 33144, United States
NorthShore University-Endeavor Health Evanston Hospital /ID# 277995
RECRUITING

Evanston, Illinois, 60201, United States
Novant Health New Hanover Regional Medical Center /ID# 261979
RECRUITING

Wilmington, North Carolina, 28401-7407, United States
Prisma Health Greenville Memorial Hospital /ID# 261995
RECRUITING

Greenville, South Carolina, 29605-4210, United States
University of Florida - Jacksonville /ID# 261992
COMPLETED

Jacksonville, Florida, 32209, United States

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