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Could a muscle relaxant cut opioid use after hernia surgery?

NCT ID NCT05388929

Symptom relief Sponsor: Prisma Health-Upstate Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether adding methocarbamol, a muscle relaxant, to standard pain relief can reduce the need for opioids after ventral or inguinal hernia repair. Adults undergoing surgery are randomly assigned to receive either standard opioids, methocarbamol alone, or both. The study tracks how many people need extra opioid prescriptions and their total opioid use over 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Methocarbamol
What this could lead to
If it works, this could point toward a way to reduce opioid use after hernia surgery, lowering the risk of addiction and side effects.
What could go wrong
This is a small pilot study, so results may not be conclusive. Methocarbamol may not reduce pain or opioid needs, and could cause side effects like drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

164 people

The number who actually took part.

Started

Jun 2022

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>18 y/o * Patients undergoing open primary ventral hernia repair (group 1) * Patients undergoing inguinal hernia repair (open, laparoscopic, or robotic; group 2) * Patients undergoing open incisional hernia repair (group 3) * Robotic repair ventral or incisional hernias (group 4) * Given consent for randomization Exclusion Criteria: * \<18 y/o * Pregnancy * Chronic opioid users

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Conditions

The condition(s) this trial relates to.

Hernia, Inguinal Hernia, Ventral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inguinal hernia Ventral hernia

Contacts and locations

Locations

  • Prisma Health

    Greenville, South Carolina, 29615, United States

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