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Reading the machine's breath: a new way to foresee post-surgery lung failure?

NCT ID NCT07799636

Knowledge-focused Sponsor: West China Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study at West China Hospital follows 250 adults who need a breathing machine after major surgery. Researchers will record the machine's waveforms, which show how air moves in and out of the lungs, and check whether certain patterns warn of respiratory failure. The goal is to see if these images can help doctors act earlier and tailor breathing support to each patient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No drug or device is being tested. The study observes ventilator waveform images from patients after surgery to see if they can predict respiratory failure.
What this could lead to
If ventilator waveforms can flag early signs of trouble, doctors might spot postoperative respiratory failure sooner and tailor breathing support to each patient.
What could go wrong
This is an observational study, so it can show links but not prove cause and effect. The findings may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of patients receiving mechanical ventilation who are transferred to the ICU after surgery at our hospital. To ensure adequate representation of different surgical types and disease severity levels and to facilitate subsequent stratified analyses, stratified consecutive enrollment will be adopted.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years; * Patients receiving mechanical ventilation after surgery and transferred directly to the ICU; * Patients expected to require or actually requiring mechanical ventilation for more than 24 hours after surgery; * Patients or their legally authorized representatives providing written informed consent. Exclusion Criteria: * Respiratory failure occurring before surgery; * Severe pulmonary disease diagnosed before surgery, including but not limited to severe chronic obstructive pulmonary disease (COPD; GOLD stage 3-4), severe interstitial lung disease (PaO₂/FiO₂ \<300 mmHg), active pneumonia, and severe pulmonary hypertension; * Preoperative mechanical ventilation for \>48 hours; * A decision made immediately after surgery to withhold or withdraw active treatment, including invasive mechanical ventilation; * Expected survival of less than 48 hours; * Inability to connect to or record the required ventilator waveform data and/or electronic medical record data; * Other severe underlying diseases, including but not limited to end-stage liver disease, dialysis-dependent renal failure, and advanced malignancy with a short expected survival.

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative respiratory failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chi Zhang

    RECRUITING

    Chengdu, Sichuan, 610041, China

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