Shock device may free ICU patients from ventilators faster

NCT ID NCT05759013

Completed Symptom relief Sponsor: Liberate Medical Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a device called VentFree that uses mild electrical pulses to strengthen breathing muscles in critically ill patients on ventilators. 250 adults who had been on a ventilator for 1 to 4 days were randomly assigned to receive either real or sham (fake) treatment. The goal was to see if the device could help them wean off the ventilator sooner and improve cough strength.

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Conditions

The condition(s) this trial relates to.

Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATION, ARTIFICIAL VENTILATORS, MECHANICAL

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Canisius Wilhelmina Ziekenhuis (CWZ)

Nijmegen, Netherlands
Centre Hospitalier Universitaire d'Angers

Angers, 49933, France
Edward Hines, Jr. VA Hospital

Hines, Illinois, 60141, United States
Erasmus Medical Center

Rotterdam, Netherlands
Houston Methodist Hospital

Houston, Texas, 77030, United States
Hôpital Saint Joseph Saint Luc

Lyon, 69365, France
Jeroen Bosch Ziekenhuis (JBZ)

's-Hertogenbosch, Netherlands
Loyola University

Maywood, Illinois, 60153, United States
MD Anderson Cancer Center

Houston, Texas, 077030, United States
Memorial Hermann

Houston, Texas, 77030, United States
MemorialCare Long Beach Medical Center

Long Beach, California, 90807, United States
Monash Medical Centre

Clayton, Australia
Nepean Hospital

Kingswood, Australia
Pitié-Salpêtrière University Hospital

Paris, France
Prince of Wales Hospital

Randwick, Australia
Providence Regional Medical Center

Everett, Washington, 98201, United States
Radboud University Medical Center

Nijmegen, Netherlands
Royal North Shore Hospital

St Leonards, Australia
St. George Hospital

Kogarah, Australia
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University of Cincinnati

Cincinnati, Ohio, 45221, United States
University of Florida College of Medicine - Jacksonville

Jacksonville, Florida, 32206, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15260, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Weill Cornell Medicine / New York Presbyterian Hospital

New York, New York, 10065, United States

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