Experimental virus therapy for advanced cancers shows early safety data
NCT ID NCT05346484
First seen Jan 10, 2026 · Last updated May 21, 2026 · Updated 12 times
Summary
This early-stage study tested an experimental virus therapy called VAXINIA (CF33-hNIS) in 66 adults with advanced solid tumors that had spread. The virus was given either directly into tumors or through a vein, alone or with the immunotherapy drug pembrolizumab. The main goal was to check safety and find the best dose, but the study was stopped early. It was not designed to cure the disease, and patients with these cancers typically need ongoing treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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City of Hope Medical Center
Duarte, California, 91010, United States
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Corewell Health
Grand Rapids, Michigan, 49503, United States
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Highlands Oncology
Springdale, Arkansas, 72762, United States
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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NEXT Oncology
Fairfax, Virginia, 22031, United States
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St. Vincent's Hospital
Fitzroy, Victoria, 3065, Australia
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Tasman Oncology Research
Southport, Queensland, 4215, Australia
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UC San Diego Moores Cancer Center
La Jolla, California, 92093-0698, United States
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University of Arizona Cancer Center
Tucson, Arizona, 85724-5024, United States
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University of Cincinnati
Cincinnati, Ohio, 45219, United States
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University of Miami
Miami, Florida, 33136, United States
Conditions
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