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Which blood pressure drug spares the lungs during heart surgery?

NCT ID NCT04501861

Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This trial tests whether vasopressin or norepinephrine is better at raising blood pressure without straining the lungs' blood vessels in adults having elective cardiac surgery. Participants receive one of the two drugs as a continuous infusion when their blood pressure drops during surgery. Researchers measure the pressure in the lung arteries relative to the body's blood pressure and check right heart function to see which drug offers a safer balance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vasopressin and norepinephrine, two drugs that raise blood pressure during surgery
What this could lead to
If vasopressin proves gentler on the lungs' blood vessels, it could become the preferred drug to support blood pressure during cardiac surgery, potentially reducing heart and lung complications.
What could go wrong
This is a single-center quality project, not a large definitive trial. Results may not apply to all cardiac surgery patients, and both drugs carry risks like altered blood flow or heart rhythm issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

164 people

The number who actually took part.

Started

Nov 2020

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: Adults\> 18 years of age * Elective cardiac surgery with the use of CPB * Patients with pulmonary artery catheter insertion * Systemic hypotension (MAP \< 70 mmHg) requiring continuous infusion of vasopressor Exclusion Criteria: * Transplant surgery * Ventricular assist device implantation other than intra-aortic balloon counter-pulsation * Pulmonary endarterectomy * Thoracoabdominal aneurysm repair * Inhalational pulmonary vasodilators (e.g. Epoprostenol) administration before insertion of pulmonary artery catheter * Vasopressin is started as the first choice of pressor per clinical staff discretion

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Conditions

The condition(s) this trial relates to.

heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac disease

Contacts and locations

Locations

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

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