Promising combo targets tough lymphoma in seniors
NCT ID NCT03567876
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding the targeted drug venetoclax to standard chemotherapy (R-BAC) helps older patients with high-risk mantle cell lymphoma. 141 patients received the combination, aiming to improve how long they stay cancer-free. The approach is designed for those who cannot tolerate intensive treatments like stem cell transplants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Venetoclax (a targeted drug) combined with rituximab, bendamustine, and cytarabine (chemotherapy)
What this could lead to
If successful, this combination could help older patients with high-risk mantle cell lymphoma live longer without their cancer progressing.
What could go wrong
This is a phase 2 trial with 141 patients, so results are still preliminary. The added drug may increase side effects without guaranteeing better outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O. Ospedali Riuniti Villa Sofia-Cervello, Divisione di Ematologia
Palermo, Italy
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A.O. SS. Antonio e Biagio e Cesare Arrigo, SC Ematologia
Alessandria, Italy
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A.O.U. Città della Salute e della Scienza di Torino, SC Ematologia
Torino, Italy
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A.O.U. Città della Salute e della Scienza di Torino, SC Ematologia Universitaria
Torino, Italy
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AOU Maggiore della Carità di Novara, SCDU Ematologia
Novara, Italy
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ASST Grande Ospedale Metropolitano Niguarda, SC Ematologia
Milan, Italy
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ASST Spedali Civili, Ematologia
Brescia, Italy
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Azienda Ospedaliera C. Panico, UOC Ematologia e Trapianto
Tricase, Italy
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Azienda Ospedaliera S. Croce e Carle, SC Ematologia
Cuneo, Italy
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Azienda Ospedaliera Universitaria Careggi, Unità funzionale di Ematologia
Florence, Italy
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Azienda Ospedaliera Universitaria Integrata di Verona, UO Ematologia
Verona, Italy
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Azienda Ospedaliera Universitaria di Padova, Ematologia
Padova, Italy
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Azienda Sanitaria Universitaria Integrata di Udine, Clinica Ematologica
Udine, Italy
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Azienda Unità Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova, Ematologia
Reggio Emilia, Italy
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Centro Riferimento Oncologico, S.O.C. Oncologia Medica A
Aviano, Italy
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Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Ematologia
Milan, Italy
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Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Ematologia
Reggio Calabria, Italy
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IRCCS Istituto Tumori Giovanni Paolo II, UOC Ematologia
Bari, Italy
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IRCCS Policlinico S. Matteo, Divisione di Ematologia
Pavia, Italy
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Istituto Clinico Humanitas, UO Ematologia
Rozzano, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.), Ematologia
Meldola, Italy
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Istituto Scientifico San Raffaele, Unità Linfomi - Dipartimento Oncoematologia
Milan, Italy
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Ospedale Businco, Ematologia
Cagliari, Italy
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Ospedale Ca' Foncello, SC Ematologia
Treviso, Italy
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Ospedale Guglielmo Da Saliceto, UO Ematologia
Piacenza, Italy
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Ospedale Maggiore Policlinico - Fondazione IRCCS Ca' Granda, Ematologia
Milan, Italy
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Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'Oncologia, Clinica Ematologica
Genova, Italy
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Ospedale San Bortolo, Divisione di Ematologia
Vicenza, Italy
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Ospedale degli Infermi, UO Ematologia
Rimini, Italy
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Ospedale delle Croci, Ematologia
Ravenna, Italy
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Ospedale di Circolo, UOC Ematologia
Varese, Italy
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Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seragnoli"
Bologna, Italy
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Policlinico Umberto I - Università "La Sapienza", Istituto Ematologia -Dipartimento di Biotecnologie Cellulari ed Ematologia
Roma, Italy
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Università Cattolica S. Cuore, Ematologia
Roma, Italy
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Università Politecnica delle Marche, Clinica di Ematologia
Ancona, Italy