New hope for kids with severe bowel disease

NCT ID NCT05782907

Summary

This study is testing the safety and effectiveness of the drug upadacitinib for children with moderate-to-severe ulcerative colitis who haven't responded well to other standard treatments. About 110 children worldwide will take the medication daily and be closely monitored for over a year to see if their symptoms improve and if the drug is safe. The goal is to control the disease and reduce inflammation in the colon.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AP-HP - Hopital Necker /ID# 251658

    Paris, 75015, France

  • Agia Sofia Hospital /ID# 250697

    Athens, Attica, 11527, Greece

  • Alberta Health Services /ID# 252088

    Edmonton, Alberta, T6G 1C9, Canada

  • Amsterdam UMC, locatie AMC /ID# 250845

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Ann & Robert H. Lurie Children's Hospital of Chicago /ID# 254505

    Chicago, Illinois, 60611, United States

  • Arkansas Children's Hospital /ID# 250106

    Little Rock, Arkansas, 72202, United States

  • Azienda Ospedaliero Universitaria Meyer /ID# 251624

    Florence, Firenze, 50139, Italy

  • Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 251625

    Rome, Roma, 00161, Italy

  • BC Children's Hospital /ID# 250947

    Vancouver, British Columbia, V6H 3V4, Canada

  • Birmingham Women's and Children's NHS Foundation Trust /ID# 253072

    Birmingham, B4 6NH, United Kingdom

  • Boston Children's Hospital /ID# 250108

    Boston, Massachusetts, 02115, United States

  • CHU Bordeaux - Hopital Pellegrin /ID# 253182

    Bordeaux, Nouvelle-Aquitaine, 33076, France

  • CHU Toulouse - Hopital Paule de Viguier /ID# 252070

    Toulouse, 31059, France

  • Charite Universitaetsmedizin Berlin Campus Virchow-Klinikum /ID# 251434

    Berlin, 13353, Germany

  • Children's Hospital Colorado - Aurora /ID# 250110

    Aurora, Colorado, 80045, United States

  • Children's Hospital at Westmead /ID# 255556

    Westmead, New South Wales, 2145, Australia

  • Children's Hospital of Philadelphia - Main /ID# 258773

    Philadelphia, Pennsylvania, 19104-4319, United States

  • Children's Specialty Group /ID# 256966

    Norfolk, Virginia, 23507, United States

  • Childrens Healthcare of Atlanta - Center for Advanced Pediatrics /ID# 255069

    Atlanta, Georgia, 30329, United States

  • Christchurch Hospital. /ID# 254703

    Christchurch, Canterbury, 8011, New Zealand

  • Clinical Research Puerto Rico /ID# 266477

    San Juan, 00909-1711, Puerto Rico

  • Debreceni Egyetem-Klinikai Kozpont /ID# 251835

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 251917

    London, Greater London, E1 2ES, United Kingdom

  • Dr. von Haunerschen Kinderspital /ID# 251440

    Munich, Bavaria, 80337, Germany

  • Fakultní Nemocnice Plzeň-Lochotín /ID# 253284

    Pilsen, Plzen-jih, 323 00, Czechia

  • Fakultní nemocnice v Motole /ID# 251955

    Prague, Praha 5, 150 06, Czechia

  • Gastromed Sp. z o.o /ID# 251290

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • Great Ormond Street Children's Hospital /ID# 252126

    London, Greater London, WC1N 3HZ, United Kingdom

  • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 251928

    Sapporo, Hokkaido, 060-0033, Japan

  • Hopitaux de Paris (AP-HP) - Hopital Robert Debre - CHU /ID# 252069

    Paris, 75019, France

  • Hospices Civils de Lyon - Hôpital Femme Mère Enfant /ID# 251502

    Bron, Rhone, 69500, France

  • Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 252105

    Ferrol, A Coruna, 15405, Spain

  • Hospital Pequeno Príncipe /ID# 251911

    Curitiba, Paraná, 80250-060, Brazil

  • Hospital Regional Universitario de Malaga /ID# 251193

    Málaga, 29011, Spain

  • Hospital Sant Joan de Deu /ID# 251194

    Esplugues de Llobregat, Barcelona, 08950, Spain

  • Hospital Universitario Vall de Hebron /ID# 252104

    Barcelona, 08035, Spain

  • Hospital e Maternidade Celso Pierro - PUC-Campinas /ID# 251912

    Campinas, São Paulo, 13034-685, Brazil

  • Hospital for Sick Children /ID# 250945

    Toronto, Ontario, M5G 1X8, Canada

  • IWK Health Center /ID# 250943

    Halifax, Nova Scotia, B3K 6R8, Canada

  • Institute of Science Tokyo Hospital /ID# 251929

    Bunkyo-ku, Tokyo, 113-8519, Japan

  • Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 251289

    Warsaw, Masovian Voivodeship, 04-730, Poland

  • Kindred Medical Institute - Corona /ID# 255484

    Corona, California, 92879-3104, United States

  • Klinikum St. Georg gGmbH /ID# 262481

    Leipzig, Saxony, 04129, Germany

  • Kurume University Hospital /ID# 251927

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Kyungpook National University Chilgok Hospital /ID# 252663

    Daegu, 41404, South Korea

  • Levine Children's Hospital /ID# 250131

    Charlotte, North Carolina, 28203, United States

  • Linkou Chang Gung Memorial Hospital /ID# 251654

    Taoyuan, 333, Taiwan

  • Lucile Packard Children's Hospital /ID# 258430

    Palo Alto, California, 94304, United States

  • Massachusetts General Hospital /ID# 250142

    Boston, Massachusetts, 02114, United States

  • Miyagi Children's Hospital /ID# 251931

    Sendai, Miyagi, 989-3126, Japan

  • Monash Health - Monash Medical Centre /ID# 254726

    Clayton, Victoria, 3168, Australia

  • NYU Langone Hospital - Long Island /ID# 250136

    Mineola, New York, 11501, United States

  • National Center For Child Health And Development /ID# 251926

    Setagaya City, Tokyo, 157-8535, Japan

  • National Taiwan University Hospital /ID# 251650

    Taipei City, Taipei, 100, Taiwan

  • Nemours/Alfred duPont Hospital for Children /ID# 255483

    Wilmington, Delaware, 19803, United States

  • OSF St. Francis Medical Center /ID# 256968

    Peoria, Illinois, 61637-0001, United States

  • Osaka General Medical Center /ID# 253678

    Osaka, Osaka, 558-8558, Japan

  • Osaka Women's and Children's Hospital /ID# 252397

    Izumi-Shi, Osaka, 594-1101, Japan

  • Ospedale Maggiore Carlo Alberto Pizzardi /ID# 251626

    Bologna, 40133, Italy

  • Perth Children'S Hospital /ID# 254727

    Perth, Western Australia, 6009, Australia

  • Phoenix Children's Hospital /ID# 250135

    Phoenix, Arizona, 85016-7710, United States

  • Queensland Children's Hospital /ID# 261032

    South Brisbane, Queensland, 4101, Australia

  • Rocco & Nazato Servicos Medicos /ID# 251910

    São Paulo, São Paulo, 04543-011, Brazil

  • Saitama Children's Medical Center /ID# 252362

    Saitama-shi, Saitama, 330-8777, Japan

  • Samsung Medical Center /ID# 252023

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Schneider Children's Medical Center /ID# 254833

    Petah Tikva, Central District, 4920235, Israel

  • Semmelweis Egyetem /ID# 251083

    Budapest, 1085, Hungary

  • Seoul National University Hospital /ID# 252024

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Servicios de Oncologia Medica Integral SA de CV /ID# 252974

    San Pedro Garza García, Nuevo León, 66220, Mexico

  • Shaare Zedek Medical Center /ID# 254832

    Jerusalem, Jerusalem, 91031, Israel

  • Sheffield Children's Hospital NHS Foundation Trust /ID# 251600

    Sheffield, England, S10 2TH, United Kingdom

  • South Edmonton Gastroenterology /ID# 276669

    Edmonton, Alberta, T6L 6K3, Canada

  • Specialized Hospital For Active Treatment Of Children Diseases Prof. Ivan Mitev /ID# 251285

    Sofia, 1606, Bulgaria

  • Starship Child Health /ID# 254702

    Auckland, 0629, New Zealand

  • The Mount Sinai Hospital /ID# 250141

    New York, New York, 10029, United States

  • Tokyo Metropolitan Children's Medical Center /ID# 252477

    Fuchu-shi, Tokyo, 183-8561, Japan

  • Tsujinaka Hospital - Kashiwanoha /ID# 251930

    Kashiwa-shi, Chiba, 277-0871, Japan

  • UCSF Benioff Children's Hospital - Oakland /ID# 255067

    Oakland, California, 94609, United States

  • UH Cleveland Medical Center /ID# 250134

    Cleveland, Ohio, 44106, United States

  • UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 251948

    Varna, 9009, Bulgaria

  • UMHAT Sveti Georgi /ID# 251949

    Plovdiv, 4002, Bulgaria

  • Univ NC Chapel Hill /ID# 254541

    Chapel Hill, North Carolina, 27514-4220, United States

  • Universitaetsklinikum Muenster /ID# 256763

    Münster, North Rhine-Westphalia, 48149, Germany

  • Universitair Medisch Centrum Groningen /ID# 252003

    Groningen, 9713 GZ, Netherlands

  • Universitair Ziekenhuis Antwerpen /ID# 251184

    Edegem, Antwerpen, 2650, Belgium

  • Universitair Ziekenhuis Leuven /ID# 251185

    Leuven, Vlaams-Brabant, 3000, Belgium

  • University General Hospital of Heraklion PA.G.N.I /ID# 250696

    Heraklion, Crete, 71500, Greece

  • University Hospital Southampton NHS Foundation Trust /ID# 252097

    Southampton, Hampshire, SO16 6YD, United Kingdom

  • University of Wisconsin - Madison /ID# 250632

    Madison, Wisconsin, 53715-1218, United States

Conditions

Explore the condition pages connected to this study.