New hope for kids with severe bowel disease
NCT ID NCT05782907
Summary
This study is testing the safety and effectiveness of the drug upadacitinib for children with moderate-to-severe ulcerative colitis who haven't responded well to other standard treatments. About 110 children worldwide will take the medication daily and be closely monitored for over a year to see if their symptoms improve and if the drug is safe. The goal is to control the disease and reduce inflammation in the colon.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AP-HP - Hopital Necker /ID# 251658
Paris, 75015, France
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Agia Sofia Hospital /ID# 250697
Athens, Attica, 11527, Greece
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Alberta Health Services /ID# 252088
Edmonton, Alberta, T6G 1C9, Canada
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Amsterdam UMC, locatie AMC /ID# 250845
Amsterdam, North Holland, 1105 AZ, Netherlands
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Ann & Robert H. Lurie Children's Hospital of Chicago /ID# 254505
Chicago, Illinois, 60611, United States
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Arkansas Children's Hospital /ID# 250106
Little Rock, Arkansas, 72202, United States
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Azienda Ospedaliero Universitaria Meyer /ID# 251624
Florence, Firenze, 50139, Italy
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Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 251625
Rome, Roma, 00161, Italy
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BC Children's Hospital /ID# 250947
Vancouver, British Columbia, V6H 3V4, Canada
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Birmingham Women's and Children's NHS Foundation Trust /ID# 253072
Birmingham, B4 6NH, United Kingdom
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Boston Children's Hospital /ID# 250108
Boston, Massachusetts, 02115, United States
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CHU Bordeaux - Hopital Pellegrin /ID# 253182
Bordeaux, Nouvelle-Aquitaine, 33076, France
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CHU Toulouse - Hopital Paule de Viguier /ID# 252070
Toulouse, 31059, France
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Charite Universitaetsmedizin Berlin Campus Virchow-Klinikum /ID# 251434
Berlin, 13353, Germany
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Children's Hospital Colorado - Aurora /ID# 250110
Aurora, Colorado, 80045, United States
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Children's Hospital at Westmead /ID# 255556
Westmead, New South Wales, 2145, Australia
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Children's Hospital of Philadelphia - Main /ID# 258773
Philadelphia, Pennsylvania, 19104-4319, United States
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Children's Specialty Group /ID# 256966
Norfolk, Virginia, 23507, United States
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Childrens Healthcare of Atlanta - Center for Advanced Pediatrics /ID# 255069
Atlanta, Georgia, 30329, United States
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Christchurch Hospital. /ID# 254703
Christchurch, Canterbury, 8011, New Zealand
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Clinical Research Puerto Rico /ID# 266477
San Juan, 00909-1711, Puerto Rico
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Debreceni Egyetem-Klinikai Kozpont /ID# 251835
Debrecen, Hajdú-Bihar, 4032, Hungary
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Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 251917
London, Greater London, E1 2ES, United Kingdom
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Dr. von Haunerschen Kinderspital /ID# 251440
Munich, Bavaria, 80337, Germany
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Fakultní Nemocnice Plzeň-Lochotín /ID# 253284
Pilsen, Plzen-jih, 323 00, Czechia
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Fakultní nemocnice v Motole /ID# 251955
Prague, Praha 5, 150 06, Czechia
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Gastromed Sp. z o.o /ID# 251290
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
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Great Ormond Street Children's Hospital /ID# 252126
London, Greater London, WC1N 3HZ, United Kingdom
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Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 251928
Sapporo, Hokkaido, 060-0033, Japan
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Hopitaux de Paris (AP-HP) - Hopital Robert Debre - CHU /ID# 252069
Paris, 75019, France
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Hospices Civils de Lyon - Hôpital Femme Mère Enfant /ID# 251502
Bron, Rhone, 69500, France
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Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 252105
Ferrol, A Coruna, 15405, Spain
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Hospital Pequeno Príncipe /ID# 251911
Curitiba, Paraná, 80250-060, Brazil
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Hospital Regional Universitario de Malaga /ID# 251193
Málaga, 29011, Spain
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Hospital Sant Joan de Deu /ID# 251194
Esplugues de Llobregat, Barcelona, 08950, Spain
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Hospital Universitario Vall de Hebron /ID# 252104
Barcelona, 08035, Spain
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Hospital e Maternidade Celso Pierro - PUC-Campinas /ID# 251912
Campinas, São Paulo, 13034-685, Brazil
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Hospital for Sick Children /ID# 250945
Toronto, Ontario, M5G 1X8, Canada
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IWK Health Center /ID# 250943
Halifax, Nova Scotia, B3K 6R8, Canada
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Institute of Science Tokyo Hospital /ID# 251929
Bunkyo-ku, Tokyo, 113-8519, Japan
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Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 251289
Warsaw, Masovian Voivodeship, 04-730, Poland
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Kindred Medical Institute - Corona /ID# 255484
Corona, California, 92879-3104, United States
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Klinikum St. Georg gGmbH /ID# 262481
Leipzig, Saxony, 04129, Germany
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Kurume University Hospital /ID# 251927
Kurume-shi, Fukuoka, 830-0011, Japan
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Kyungpook National University Chilgok Hospital /ID# 252663
Daegu, 41404, South Korea
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Levine Children's Hospital /ID# 250131
Charlotte, North Carolina, 28203, United States
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Linkou Chang Gung Memorial Hospital /ID# 251654
Taoyuan, 333, Taiwan
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Lucile Packard Children's Hospital /ID# 258430
Palo Alto, California, 94304, United States
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Massachusetts General Hospital /ID# 250142
Boston, Massachusetts, 02114, United States
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Miyagi Children's Hospital /ID# 251931
Sendai, Miyagi, 989-3126, Japan
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Monash Health - Monash Medical Centre /ID# 254726
Clayton, Victoria, 3168, Australia
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NYU Langone Hospital - Long Island /ID# 250136
Mineola, New York, 11501, United States
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National Center For Child Health And Development /ID# 251926
Setagaya City, Tokyo, 157-8535, Japan
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National Taiwan University Hospital /ID# 251650
Taipei City, Taipei, 100, Taiwan
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Nemours/Alfred duPont Hospital for Children /ID# 255483
Wilmington, Delaware, 19803, United States
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OSF St. Francis Medical Center /ID# 256968
Peoria, Illinois, 61637-0001, United States
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Osaka General Medical Center /ID# 253678
Osaka, Osaka, 558-8558, Japan
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Osaka Women's and Children's Hospital /ID# 252397
Izumi-Shi, Osaka, 594-1101, Japan
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Ospedale Maggiore Carlo Alberto Pizzardi /ID# 251626
Bologna, 40133, Italy
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Perth Children'S Hospital /ID# 254727
Perth, Western Australia, 6009, Australia
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Phoenix Children's Hospital /ID# 250135
Phoenix, Arizona, 85016-7710, United States
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Queensland Children's Hospital /ID# 261032
South Brisbane, Queensland, 4101, Australia
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Rocco & Nazato Servicos Medicos /ID# 251910
São Paulo, São Paulo, 04543-011, Brazil
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Saitama Children's Medical Center /ID# 252362
Saitama-shi, Saitama, 330-8777, Japan
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Samsung Medical Center /ID# 252023
Seoul, Seoul Teugbyeolsi, 06351, South Korea
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Schneider Children's Medical Center /ID# 254833
Petah Tikva, Central District, 4920235, Israel
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Semmelweis Egyetem /ID# 251083
Budapest, 1085, Hungary
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Seoul National University Hospital /ID# 252024
Seoul, Seoul Teugbyeolsi, 03080, South Korea
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Servicios de Oncologia Medica Integral SA de CV /ID# 252974
San Pedro Garza García, Nuevo León, 66220, Mexico
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Shaare Zedek Medical Center /ID# 254832
Jerusalem, Jerusalem, 91031, Israel
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Sheffield Children's Hospital NHS Foundation Trust /ID# 251600
Sheffield, England, S10 2TH, United Kingdom
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South Edmonton Gastroenterology /ID# 276669
Edmonton, Alberta, T6L 6K3, Canada
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Specialized Hospital For Active Treatment Of Children Diseases Prof. Ivan Mitev /ID# 251285
Sofia, 1606, Bulgaria
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Starship Child Health /ID# 254702
Auckland, 0629, New Zealand
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The Mount Sinai Hospital /ID# 250141
New York, New York, 10029, United States
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Tokyo Metropolitan Children's Medical Center /ID# 252477
Fuchu-shi, Tokyo, 183-8561, Japan
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Tsujinaka Hospital - Kashiwanoha /ID# 251930
Kashiwa-shi, Chiba, 277-0871, Japan
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UCSF Benioff Children's Hospital - Oakland /ID# 255067
Oakland, California, 94609, United States
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UH Cleveland Medical Center /ID# 250134
Cleveland, Ohio, 44106, United States
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UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 251948
Varna, 9009, Bulgaria
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UMHAT Sveti Georgi /ID# 251949
Plovdiv, 4002, Bulgaria
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Univ NC Chapel Hill /ID# 254541
Chapel Hill, North Carolina, 27514-4220, United States
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Universitaetsklinikum Muenster /ID# 256763
Münster, North Rhine-Westphalia, 48149, Germany
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Universitair Medisch Centrum Groningen /ID# 252003
Groningen, 9713 GZ, Netherlands
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Universitair Ziekenhuis Antwerpen /ID# 251184
Edegem, Antwerpen, 2650, Belgium
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Universitair Ziekenhuis Leuven /ID# 251185
Leuven, Vlaams-Brabant, 3000, Belgium
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University General Hospital of Heraklion PA.G.N.I /ID# 250696
Heraklion, Crete, 71500, Greece
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University Hospital Southampton NHS Foundation Trust /ID# 252097
Southampton, Hampshire, SO16 6YD, United Kingdom
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University of Wisconsin - Madison /ID# 250632
Madison, Wisconsin, 53715-1218, United States
Conditions
Explore the condition pages connected to this study.