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Could a daily pill tame severe eczema in kids?

NCT ID NCT06701331

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether upadacitinib (Rinvoq), a daily pill already used in older patients, can safely improve moderate to severe eczema in children aged 2 to 11 in Japan. About 99 kids will receive either the drug or a placebo, plus a steroid cream, for up to a year. Researchers will measure skin clearing and watch for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
upadacitinib (Rinvoq) taken as a tablet or oral solution
What this could lead to
If it works, this could offer a new treatment option for children with stubborn eczema that isn't controlled by creams alone.
What could go wrong
This is a relatively small, early-phase study in Japan only. Upadacitinib has known risks like infections and allergic reactions, and it's not yet proven for this age group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

Locations

  • Aoi Dermatology Clinic /ID# 274265

    Kamimashiki-gun, Kumamoto, 861-2236, Japan

  • Central Clinic - Nagoya /ID# 269205

    Nagoya, Aichi-ken, 464-0821, Japan

  • Dermatology and Ophthalmology Kume Clinic /ID# 271854

    Sakai-shi, Osaka, 593-8324, Japan

  • Dokkyo Medical University Hospital /ID# 270367

    Mibu, Tochigi, 321-0293, Japan

  • Fujita Health University Hospital /ID# 269201

    Toyoake, Aichi-ken, 470-1192, Japan

  • Fukuwa Clinic /ID# 269203

    Chuo-ku, Tokyo, 103-0031, Japan

  • Gunma University Hospital /ID# 272319

    Maebashi, Gunma, 371-8511, Japan

  • Hayami Dermatology Clinic /ID# 269945

    Higashinari-ku, Osaka, 537-0013, Japan

  • Hirase Allergie Children's Clinic /ID# 271208

    Kobe, Hyōgo, 653-0836, Japan

  • Hoshikuma Dermatology ・ Allergy Clinic /ID# 270192

    Fukuoka, Fukuoka, 814-0171, Japan

  • Hospital Of The University Of Occupational And Environmental Health, Japan /ID# 269206

    Kitakyushu-shi, Fukuoka, 807-8556, Japan

  • Jun Dermatology Clinic /ID# 269953

    Osaka, Osaka, 558-0003, Japan

  • Medical corporation Kojinkai Yoshioka Dermatology Clinic /ID# 269198

    Neyagawa, Osaka, 572-0838, Japan

  • Miyata Dermatology Clinic /ID# 269200

    Matsudo-Shi, Chiba, 271-0092, Japan

  • Momodani Skin Clinic /ID# 270384

    Osaka, Osaka, 543-0033, Japan

  • Musashikosugi Sasamoto Pediatric And Allergy Clinic /ID# 270381

    Kawasaki-shi, Kanagawa, 211-0004, Japan

  • National Hospital Organization Sagamihara National Hospital /ID# 271575

    Sagamihara, Kanagawa, 252-0315, Japan

  • Ryuseidai Children's Clinic /ID# 271400

    Tsukuba, Ibaraki, 305-0008, Japan

  • Saitama City Hospital /ID# 271392

    Saitama, 336-8522, Japan

  • Sapporo Shiroishi Dermatology Clinic /ID# 269691

    Sapporo, Hokkaido, 003-0026, Japan

  • Saruta Dermatology Clinic /ID# 270416

    Fukuoka, Fukuoka, 819-0042, Japan

  • Seijo Sasamoto Pediatric Allergy Clinic /ID# 270194

    Setagaya-ku, Tokyo, 157-0066, Japan

  • Takeoka Dermatology Clinic /ID# 269199

    Marugame, Kagawa-ken, 763-0074, Japan

  • Tokunaga Skin Clinic /ID# 270189

    Kasuga-shi, Fukuoka, 816-0813, Japan

  • University of Tsukuba Hospital /ID# 271238

    Tsukuba, Ibaraki, 305-8576, Japan

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